ArticleEnvironmental health and preventive medicine2012
Factors in genetic susceptibility in a chemical sensitive population using QEESI.
Article in Environmental health and preventive medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS).International journal of environmental research and public health · 2021Pooled it
- Multiple Chemical Sensitivity: Review of the State of the Art in Epidemiology, Diagnosis, and Future Perspectives.Journal of occupational and environmental medicine · 2018Pooled it
- Prevalence and Factors Related to High Risk of Multiple Chemical Sensitivity among Japanese High School Students.International journal of environmental research and public health · 2024Article
- Chemical Intolerance and Mast Cell Activation: A Suspicious Synchronicity.Journal of xenobiotics · 2023Article
- Article
- A case report of idiopathic environmental intolerance: A controversial and current issue.Clinical case reports · 2020Article
- Olfactory-Related Quality of Life in Multiple Chemical Sensitivity: A Genetic-Acquired Factors Model.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesInherited impairment of xenobiotic metabolism is a postulated mechanism underlying environmentally associated pathogeneses such as multiple chemical sensitivity (MCS). Using the Quick Environmental Exposure and Sensitivity Inventory (QEESI), we defined people who have a strong response to chemical substances as "chemical sensitive populations (CSP)." The aim of this study is to evaluate the condition of subjects sensitive to chemicals and to analyze their genotypes in order to identify susceptibility factors in CSPs in Japanese populations.
methodsA total of 1,084 employees of Japanese companies were surveyed using the QEESI, history of MCS, and sick house syndrome. The common genotypes of the participants were analyzed for glutathione S-transferase (GST) M1, GSTT1, aldehyde dehydrogenase2 (ALDH2), and paraoxonase1 (PON1) in order to identify factors in the susceptibility to sensitivity to chemicals.
resultsFour subjects had history of diagnosis of MCS; no subjects had diagnosis of sick house syndrome. The subjects were divided into four levels according to scores of 0, 1-19, 20-39, and 40 or more on three of the QEESI subscales. In addition, we used the MCS criteria by Hojo to differentiate between cases (CSP) and controls. No significant differences in the allelic distribution of genetic polymorphisms in the GSTM1, GSTT1, ALDH2 or PON1 genes were found among the four levels of each subscale, or between cases and controls.
conclusionsOur findings suggest that the common genotypes of GSTM1, GSTT1, ALDH2, and PON1 are of little importance to CSP in a Japanese population.
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