ArticlePediatric nephrology (Berlin, Germany)2012
The spectrum of HIV-related nephropathy in children.
Article in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Prevalence of HIV-associated nephropathy in children: a systematic review with meta-analysis of studies published between 2004 and 2019.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Effects of cholecalciferol supplementation on serum and urinary vitamin D metabolites and binding protein in HIV-infected youth.The Journal of steroid biochemistry and molecular biology · 2017Trial
- Clinical Characteristics, Pathological Features and Treatment Outcomes of Children With Nephrotic Syndrome at Princess Marina Hospital, Botswana.Global pediatric health · 2024Article
- Etiology of Kidney Diseases With Proteinuria in the Gambia/West Africa.Frontiers in pediatrics · 2022Article
- An adolescent boy with a mononucleosis-like syndrome and proteinuria.Paediatrics & child health · 2020Article
- Nephrotic Syndrome in South African Children: Changing Perspectives in the New Millennium.Kidney international reports · 2019Review
- Prevalence of risk factors for chronic kidney disease in South African youth with perinatally acquired HIV.Pediatric nephrology (Berlin, Germany) · 2019Article
- APOL1 polymorphisms and kidney disease: loss-of-function or gain-of-function?American journal of physiology. Renal physiology · 2019Review
- Management of drug-resistant tuberculosis in special sub-populations including those with HIV co-infection, pregnancy, diabetes, organ-specific dysfunction, and in the critically ill.Journal of thoracic disease · 2018Review
- HIV-Associated Nephropathy in Africa: Pathology, Clinical Presentation and Strategy for Prevention.Journal of clinical medicine research · 2018Review
- Recent 5-year Findings and Technological Advances in the Proteomic Study of HIV-associated Disorders.Genomics, proteomics & bioinformatics · 2017Review
- Increased Immune Activation and Exhaustion in HIV-infected Youth.The Pediatric infectious disease journal · 2016Article
- Renal abnormalities in a cohort of HIV-infected children and adolescents.Pediatric nephrology (Berlin, Germany) · 2016Article
- The etiology of congenital nephrotic syndrome: current status and challenges.World journal of pediatrics : WJP · 2016Review
- Renal abnormalities among HIV infected children at Muhimbili National Hospital (MNH)-Dar es Salaam, Tanzania.BMC nephrology · 2016Article
- FSGS: Diagnosis and Diagnostic Work-Up.BioMed research international · 2016Review
- Infection-Related Focal Segmental Glomerulosclerosis in Children.BioMed research international · 2016Review
- Renal transplantation in human immunodeficiency virus (HIV)-positive children.Pediatric nephrology (Berlin, Germany) · 2015Review
- The physical and psychological effects of HIV infection and its treatment on perinatally HIV-infected children.Journal of the International AIDS Society · 2015Article
- Pediatric Nephrology in Primary Care: The Forest for the Trees.Frontiers in public health · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the burden of human immunodeficiency virus (HIV) disease in Southern Africa, there have been few reports of HIV-related nephropathy in children. This study outlines the spectrum of HIV-1-related kidney diseases of children in KwaZulu-Natal, South Africa.
methodsA review of the clinical presentation, laboratory and histopathological findings of children diagnosed with HIV-related nephropathy.
resultsForty-nine out of 71 children (1-16 years old) with HIV-1 related nephropathy underwent kidney biopsy. The most common histopathological finding was focal segmental glomerulosclerosis (FSGS), which was present in 32 (65.3%) children; 13 (26.5%) having collapsing glomerulopathy and 19 (38.8%) classic FSGS. The majority of patients showed haematological (86.4%) and electrolyte abnormalities (69.4%). Renal impairment was present in 41% of patients on initial presentation. However, end-stage kidney disease was present in only 4% of these patients. All patients were treated with highly active anti-retroviral therapy (HAART), the majority (79.6%) showed decreased proteinuria with 38.8% having complete remission.
conclusionsThis study, one of the largest series of children reported from Africa, demonstrates that nephrotic syndrome due to HIV-associated nephropathy (HIVAN) is the commonest presentation of HIV-related nephropathy in childhood. Highly active anti-retroviral therapy in combination with angiotensin-converting enzyme antagonists is highly effective in decreasing proteinuria and preserving renal function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.