ArticleKidney international2012
Vitamin D deficiency is common in children and adolescents with chronic kidney disease.
Article in Kidney international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- The mechanisms of kidney-lung interactions in chronic kidney disease-associated pulmonary diseases: A two-sample Mendelian randomization study.Renal failure · 2025Pooled it
- Association between serum 25-hydroxyvitamin D and albuminuria in Korean adolescents: evidence from a national survey.Pediatric nephrology (Berlin, Germany) · 2026Article
- Association between serum 25-hydroxyvitamin D level and inflammatory markers in hemodialysis-treated patients.Immunity, inflammation and disease · 2024Article
- Article
- Vitamin D and Glomerulonephritis.Medicina (Kaunas, Lithuania) · 2021Review
- Association between vitamin D metabolites, vitamin D binding protein, and proteinuria in dogs.Journal of veterinary internal medicine · 2020Article
- Free 25-hydroxyvitamin-D concentrations are lower in children with renal transplant compared with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2020Article
- Vitamin D deficiency, cardiothoracic ratio, and long-term mortality in hemodialysis patients.Scientific reports · 2020Article
- Vitamin D and cardiovascular disease in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- Bone Health in Glomerular Kidney Disease.Current osteoporosis reports · 2019Review
- Inflammation, vitamin D and dendritic cell precursors in chronic kidney disease.Clinical and experimental immunology · 2016Article
- Effect of cholecalciferol on local arterial stiffness and endothelial dysfunction in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2016Article
- Fracture Burden and Risk Factors in Childhood CKD: Results from the CKiD Cohort Study.Journal of the American Society of Nephrology : JASN · 2016Article
- Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort.Pediatric nephrology (Berlin, Germany) · 2016Article
- Disordered FGF23 and mineral metabolism in children with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2014Observational
- Vitamin D bioavailability and catabolism in pediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2013Article
- Mineral metabolism and cortical volumetric bone mineral density in childhood chronic kidney disease.The Journal of clinical endocrinology and metabolism · 2013Article
- Vitamin D and inflammation.Pediatric nephrology (Berlin, Germany) · 2013Review
- Vitamin D: effects on childhood health and disease.Nature reviews. Endocrinology · 2013Review
- Changes in bone structure and the muscle-bone unit in children with chronic kidney disease.Kidney international · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Here we determined if vitamin D deficiency is more common in children with chronic kidney disease compared to healthy children. In addition, we sought to identify disease-specific risk factors for this deficiency, as well as its metabolic consequences. We found that nearly half of 182 patients (ages 5 to 21) with kidney disease (stages 2 to 5) and a third of age-matched 276 healthy children were 25-hydroxyvitamin D deficient (<20 ng/ml). The risk of deficiency was significantly greater in advanced disease. Focal segmental glomerulosclerosis and low albumin were significantly associated with lower 25-hydroxyvitamin D, which, in turn, was associated with significantly higher intact parathyroid hormone levels. We found that 25-hydroxyvitamin D levels were positively associated with 1,25-dihydroxyvitamin D, the relationship being greatest in advanced disease (significant interaction), and inversely related to those of inflammatory markers C-reactive protein and IL-6. The association with C-reactive protein persisted when adjusted for the severity of kidney disease. Thus, lower 25-hydroxyvitamin D may contribute to hyperparathyroidism, inflammation, and lower 1,25-dihydroxyvitamin D in children and adolescents, especially those with advanced kidney disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.