ArticleNeuroradiology2012
Semi-automatic quantitative measurements of intracranial internal carotid artery stenosis and calcification using CT angiography.
Article in Neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Intracranial Arterial Calcification and Its Impact on Subsequent Ischemic Cerebral Events: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Intracranial Arterial Calcification and Intracranial Atherosclerosis: Close but Different.Frontiers in neurology · 2022Article
- Automated Segmentation and Volume Measurement of Intracranial Internal Carotid Artery Calcification at Noncontrast CT.Radiology. Artificial intelligence · 2021Article
- Circumferential degree of carotid calcification is associated with new ischemic brain lesions after carotid artery stenting.Quantitative imaging in medicine and surgery · 2021Article
- Histology-Verified Intracranial Artery Calcification and Its Clinical Relevance With Cerebrovascular Disease.Frontiers in neurology · 2021Review
- Overcoming calcium blooming and improving the quantification accuracy of percent area luminal stenosis by material decomposition of multi-energy computed tomography datasets.Journal of medical imaging (Bellingham, Wash.) · 2020Article
- Association between Intracranial Atherosclerotic Calcium Burden and Angiographic Luminal Stenosis Measurements.AJNR. American journal of neuroradiology · 2017Article
- Intracranial Artery Calcification and Its Clinical Significance.Journal of clinical neurology (Seoul, Korea) · 2016Review
- Diagnostic Accuracy of 4 Commercially Available Semiautomatic Packages for Carotid Artery Stenosis Measurement on CTA.AJNR. American journal of neuroradiology · 2015Article
- Article
- Feasibility of assessment of conjunctival microvascular hemodynamics in unilateral ischemic stroke.Microvascular research · 2015Article
- Intracranial carotid artery disease in patients with recent neurological symptoms: high prevalence on CTA.Neuroradiology · 2013Article
- Quantification of intracranial internal carotid artery calcification on brain unenhanced CT: evaluation of its feasibility and assessment of the reliability of visual grading scales.European radiology · 2013Article
- Semiautomated Characterization of Carotid Artery Plaque Features From Computed Tomography Angiography to Predict Atherosclerotic Cardiovascular Disease Risk Score.Journal of computer assisted tomographyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIntracranial carotid artery atherosclerotic disease is an independent predictor for recurrent stroke. However, its quantitative assessment is not routinely performed in clinical practice. In this diagnostic study, we present and evaluate a novel semi-automatic application to quantitatively measure intracranial internal carotid artery (ICA) degree of stenosis and calcium volume in CT angiography (CTA) images.
methodsIn this retrospective study involving CTA images of 88 consecutive patients, intracranial ICA stenosis was quantitatively measured by two independent observers. Stenoses were categorized with cutoff values of 30% and 50%. The calcification in the intracranial ICA was qualitatively categorized as absent, mild, moderate, or severe and quantitatively measured using the semi-automatic application. Linear weighted kappa values were calculated to assess the interobserver agreement of the stenosis and calcium categorization. The average and the standard deviation of the quantitative calcium volume were calculated for the calcium categories.
resultsFor the stenosis measurements, the CTA images of 162 arteries yielded an interobserver correlation of 0.78 (P < 0.001). Kappa values of the categorized stenosis measurements were moderate: 0.45 and 0.58 for cutoff values of 30% and 50%, respectively. The kappa value for the calcium categorization was 0.62, with a good agreement between the qualitative and quantitative calcium assessment.
conclusionsQuantitative degree of stenosis measurement of the intracranial ICA on CTA is feasible with a good interobserver agreement ICA. Qualitative calcium categorization agrees well with quantitative measurements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.