ReviewThe Journal of investigative dermatology2012
25 years of epidermal stem cell research.
Review in The Journal of investigative dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Histochemical study of cingulin and CD34 in the skin of a stray Dog.Open veterinary journal · 2026Article
- Article
- ALDH3B1 protects interfollicular epidermal cells against lipid peroxidation via the NRF2 pathway.Cell stress & chaperones · 2022Article
- Transcription Factors Runx1 and Runx3 Suppress Keratin Expression in Undifferentiated Keratinocytes.International journal of molecular sciences · 2022Article
- Dental Pulp-Derived Stem Cells Reduce Inflammation, Accelerate Wound Healing and Mediate M2 Polarization of Myeloid Cells.Biomedicines · 2022Article
- ACOT7 protects epidermal stem cells against lipid peroxidation.In vitro cellular & developmental biology. Animal · 2022Article
- Epidermal stem cells maintain stemness via a biomimetic micro/nanofiber scaffold that promotes wound healing by activating the Notch signaling pathway.Stem cell research & therapy · 2021Article
- [Effects and mechanisms of polycaprolactone-cellulose acetate nanofiber scaffold loaded with rat epidermal stem cells on wound healing of full-thickness skin defects in rats].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- Hippophae rhamnoides mediate gene expression profiles against keratinocytes infection of Staphylococcus aureus.Molecular biology reports · 2021Article
- Stem Cell Therapy for Burns: Story so Far.Biologics : targets & therapy · 2021Review
- Decrease of laminin-511 in the basement membrane due to photoaging reduces epidermal stem/progenitor cells.Scientific reports · 2020Article
- Comparative gene expression profiling reveals key pathways and genes different in skin epidermal stem cells and corneal epithelial cells.Genes & genomics · 2019Article
- The Potential Role of Cycloastragenol in Promoting Diabetic Wound Repair In Vitro.BioMed research international · 2019Article
- Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells.International journal of molecular medicine · 2018Article
- A "late-but-fitter revertant cell" explains the high frequency of revertant mosaicism in epidermolysis bullosa.PloS one · 2018Article
- Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Transit-Amplifying Cells in the Fast Lane from Stem Cells towards Differentiation.Stem cells international · 2017Review
- Insight into skin cell-based osteogenesis: a review.F1000Research · 2017Review
- Epidermal stem cells (ESCs) accelerate diabetic wound healing via the Notch signalling pathway.Bioscience reports · 2016Article
- Gelatin-based Hydrogel Degradation and Tissue InteractionTheranostics · 2016Article
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1 author.
Funding
Abstract
This is a chronicle of concepts in the field of epidermal stem cell biology and a historic look at their development over time. The past 25 years have seen the evolution of epidermal stem cell science, from first fundamental studies to a sophisticated science. The study of epithelial stem cell biology was aided by the ability to visualize the distribution of stem cells and their progeny through lineage analysis studies. The excellent progress we have made in understanding epidermal stem cell biology is discussed in this article. The challenges we still face in understanding epidermal stem cells include defining molecular markers for stem and progenitor sub-populations, determining the locations and contributions of the different stem cell niches, and mapping regulatory pathways of epidermal stem cell proliferation and differentiation. However, our rapidly evolving understanding of epidermal stem cells has many potential uses that promise to translate into improved patient therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.