ArticleHistochemistry and cell biology2012
Comparative analysis of Neph gene expression in mouse and chicken development.
Article in Histochemistry and cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Structural and functional insights of the podocyte slit diaphragm complex.Tissue barriers · 2026Review
- Evaluation of the synapse adhesion molecule Kirrel3 in neurological disease.Frontiers in neurology · 2025Review
- Neph1 is required for neurite branching and is negatively regulated by the PRRXL1 homeodomain factor in the developing spinal cord dorsal horn.Neural development · 2024Article
- A zebrafish model of congenital nephrotic syndrome of the Finnish type.Frontiers in cell and developmental biology · 2022Article
- Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth's short tail mice.Human molecular genetics · 2019Article
- Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and Beyond.Frontiers in endocrinology · 2018Review
- A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.JCI insight · 2016Article
- Avian Podocytes, Which Lack Nephrin, Use Adherens Junction Proteins at Intercellular Junctions.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Nephrin Preserves Podocyte Viability and Glomerular Structure and Function in Adult Kidneys.Journal of the American Society of Nephrology : JASN · 2015Article
- Identification of novel Kirrel3 gene splice variants in adult human skeletal muscle.BMC physiology · 2014Article
- Article
- Expression of Nephrin Homologue in the Freshwater Planarian, Dugesia japonica.Acta histochemica et cytochemica · 2014Article
- The podocyte slit diaphragm--from a thin grey line to a complex signalling hub.Nature reviews. Nephrology · 2013Review
- Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility.Molecular and cellular biology · 2013Article
- Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression.Development (Cambridge, England) · 2013Article
- Life without nephrin: it's for the birds.Journal of the American Society of Nephrology : JASN · 2012Article
- Tethering membrane fusion: common and different players in myoblasts and at the synapse.Journal of neurogeneticsReview
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neph proteins are evolutionarily conserved members of the immunoglobulin superfamily of adhesion proteins and regulate morphogenesis and patterning of different tissues. They share a common protein structure consisting of extracellular immunoglobulin-like domains, a transmembrane region, and a carboxyl terminal cytoplasmic tail required for signaling. Neph orthologs have been widely characterized in invertebrates where they mediate such diverse processes as neural development, synaptogenesis, or myoblast fusion. Vertebrate Neph proteins have been described first at the glomerular filtration barrier of the kidney. Recently, there has been accumulating evidence suggesting a function of Neph proteins also outside the kidney. Here we demonstrate that Neph1, Neph2, and Neph3 are expressed differentially in various tissues during ontogenesis in mouse and chicken. Neph1 and Neph2 were found to be amply expressed in the central nervous system while Neph3 expression remained localized to the cerebellum anlage and the spinal cord. Outside the nervous system, Neph mRNAs were also differentially expressed in branchial arches, somites, heart, lung bud, and apical ectodermal ridge. Our findings support the concept that vertebrate Neph proteins, similarly to their Drosophila and C. elegans orthologs, provide guidance cues for cell recognition and tissue patterning in various organs which may open interesting perspectives for future research on Neph1-3 controlled morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.