ArticleClinical oral investigations2012
Investigation of trefoil factor expression in saliva and oral mucosal tissues of patients with oral squamous cell carcinoma.
Article in Clinical oral investigations, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Characterization of Monomeric and Dimeric Forms of the Lectin TFF1 in the Human Vagina: Possible Role for the Innate Immune Defence.International journal of molecular sciences · 2026Article
- Salivary trefoil factor family peptide 3 (TFF3) and flow rate in persons with and without obstructive sleep apnea: A preliminary study.Clinical and experimental dental research · 2023Article
- Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential.International journal of molecular sciences · 2021Review
- Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva.Cell reports · 2020Article
- Human Synovia Contains Trefoil Factor Family (TFF) Peptides 1-3 Although Synovial Membrane Only Produces TFF3: Implications in Osteoarthritis and Rheumatoid Arthritis.International journal of molecular sciences · 2019Article
- Different Forms of TFF3 in the Human Saliva: Heterodimerization with IgG Fc Binding Protein (FCGBP).International journal of molecular sciences · 2019Article
- The expression and role of trefoil factors in human tumors.Translational cancer research · 2019Review
- Prolonged Suppressive Effects of Periodontitis on Salivary TFF3 Production.European journal of dentistry · 2019Article
- Proteolytic effects of gingipains on trefoil factor family peptides.Clinical oral investigations · 2018Article
- Article
- Genome-wide gene expression profiling of tongue squamous cell carcinoma by RNA-seq.Clinical oral investigations · 2018Article
- Diagnostic value evaluation of trefoil factors family 3 for the early detection of colorectal cancer.World journal of gastroenterology · 2017Article
- Production of Monoclonal Antibodies against Human Trefoil Factor 3 and Development of a Modified-Sandwich ELISA for Detection of Trefoil Factor 3 Homodimer in Saliva.Biological procedures online · 2017Article
- Article
- Trefoil factor 3 as a novel biomarker to distinguish between adenocarcinoma and squamous cell carcinoma.Medicine · 2015Article
- Trefoil factor family peptides TFF1 and TFF3 in the nervous tissues of developing mouse embryo.Bosnian journal of basic medical sciences · 2015Article
- Increased immunoexpression of trefoil factors in salivary gland tumors.Clinical oral investigations · 2014Article
- Salivary level of interleukin-8 in oral precancer and oral squamous cell carcinoma.Clinical oral investigations · 2013Article
- Trefoils: An unexplored natural protective shield of oral cavity.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aims of our study were to determine levels of trefoil factor (TFF) peptides in saliva and oral mucosal tissues from patients with oral squamous cell carcinoma (OSCC), and to evaluate whether individual members of TFFs (TFF1, TFF2, and TFF3) might act as biomarkers of disease. MATERIALS AND
methodsSaliva samples were from 23 healthy subjects and 23 OSCC patients. Tissue samples were collected from 32 normal oral mucosa (NOM) and 32 OSCC biopsy specimens. ELISA and immunohistochemical methods were used to evaluate the expression of TFF1, TFF2, and TFF3 in saliva and oral mucosal tissues, respectively.
resultsExpression of TFF2 and TFF3 in oral mucosal tissues of OSCC patients was strongly downregulated when compared to healthy subjects (p < 0.001 and p = 0.002, respectively). However, there were no differences in levels of salivary TFF concentrations between OSCC patients and healthy subjects.
conclusionsThe present study extends previous observations, demonstrating the reduction of TFF2 and TFF3 expression in oral mucosal tissues of OSCC patients. CLINICAL RELEVANCE: These findings suggest the clinical significance of TFF2 and TFF3 molecules as negative markers of tumor progression in OSCC. Quantification of TFF levels in saliva may not be optimal in terms of diagnostic or predictive value for OSCC derived from oral mucosa.
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