ArticleCurrent neurology and neuroscience reports2012
Syndromes predisposing to pediatric central nervous system tumors: lessons learned and new promises.
Article in Current neurology and neuroscience reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 27 citations in OpenAlex.
- Genetic Predisposition to Solid Pediatric Cancers.Frontiers in oncology · 2020Review
- Pediatric High Grade Gliomas in the Context of Cancer Predisposition Syndromes.Journal of Korean Neurosurgical Society · 2018Review
- Comparative oncology: what dogs and other species can teach us about humans with cancer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Article
- Are pediatric brain tumors on the rise in the USA? Significant incidence and survival findings from the SEER database analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Medulloblastoma under Siege: Genetic and Molecular Dissection Concerning Recent Advances in Therapeutic Strategies.Journal of pediatric neurosciencesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Central nervous system (CNS) neoplasms are a leading cause of morbidity and mortality among children with cancer. In contrast to adults, a genetic basis for brain tumors is relatively common in children. A child harboring a germline mutation in a cancer-related gene will be predisposed to develop CNS tumors. These cancer predisposition syndromes are rare but pose overwhelming clinical and psychosocial challenges to families and the treating team. Recent significant advances in our understanding of the biological processes that govern these genetic conditions combined with international efforts to define and treat clinical aspects of these tumors are transforming the lives of these individuals. In this article, we summarize recent progress made for each of the major CNS tumor syndromes. We discuss the biological and clinical relevance of such advances, and suggest a comprehensive approach to a child affected by a predisposition to brain tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.