ReviewCurrent cardiology reports2012
The influence of insulin resistance, obesity, and diabetes mellitus on vascular tone and myocardial blood flow.
Review in Current cardiology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Myocardial blood flow under general anaesthesia with sevoflurane in type 2 diabetic patients: a pilot study.Cardiovascular diabetology · 2014Trial
- [Lifestyle: physical activity and training in the prevention and treatment of type 2 diabetes mellitus (Update 2026)].Wiener klinische Wochenschrift · 2026Review
- Complementary multi-omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes.Animal models and experimental medicine · 2026Article
- Effect of sampling rate during dynamic myocardial CT perfusion on coronary flow reserve and ischemia analysis.The international journal of cardiovascular imaging · 2025Article
- [Lifestyle: physical activity and training as prevention and therapy of type 2 diabetes mellitus (Update 2023)].Wiener klinische Wochenschrift · 2023Article
- [Lifestyle: physical activity and training as prevetion and therapy of type 2 diabetes mellitus (Update 2019)].Wiener klinische Wochenschrift · 2019Review
- Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Psoriasis-Related Visceral Adiposity and Arterial Inflammation: A New Adiposity Disease Entity?JACC. Cardiovascular imaging · 2018Article
- Relationship between HgbA1c and myocardial blood flow reserve in patients with type 2 diabetes mellitus: noninvasive assessment using real-time myocardial perfusion echocardiography.Journal of diabetes research · 2014Article
- Impact of obesity and bariatric surgery on metabolism and coronary circulatory function.Current cardiology reports · 2014Review
- Myocardial perfusion reserve in spared myocardium: one more tessera of the complex mosaic of LV remodelling after myocardial infarction.European journal of nuclear medicine and molecular imaging · 2013Article
- Quantitative PET/CT measures of myocardial flow reserve and atherosclerosis for cardiac risk assessment and predicting adverse patient outcomes.Current cardiology reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among individuals with cardiovascular risk factors, reductions in coronary vasodilator capacity with or without diabetes mellitus (DM) carry important diagnostic and prognostic information. Positron emission tomography (PET) myocardial perfusion imaging in concert with tracer kinetic modeling allows the assessment of absolute regional myocardial blood flow (MBF) at rest and its response to various forms of vasomotor stress. Such noninvasive evaluation of myocardial flow reserve (MFR) or the vasodilator capacity of the coronary circulation expands the possibilities of conventional scintigraphic myocardial perfusion imaging from identifying flow-limiting epicardial coronary artery lesions to understanding the underlying pathophysiology of diabetic vasculopathy, microcirculatory dysfunction, and its atherothrombotic sequelae. Invaluable mechanistic insights were recently reported with PET by unraveling important effects of insulin resistance, obesity, and DM on the function of the coronary circulation. Such noninvasive assessment of coronary circulatory dysfunction enables monitoring its response to antidiabetic medication and/or behavioral interventions related to weight, diet, and physical activity that may evolve as a promising tool for an image-guided and personalized preventive diabetic vascular care. Whether PET-guided improvement or normalization of hyperemic MBF and/or MFR will translate into improved patient outcome in DM is a laudable goal to pursue next.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.