ArticleBMC cardiovascular disorders2011
Novel association patterns of cardiac remodeling markers in patients with essential hypertension and atrial fibrillation.
Article in BMC cardiovascular disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Preoperative Antihypertensive Medication in Relation to Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: A Meta-Analysis.BioMed research international · 2017Pooled it
- The Interplay Between Periodontitis and Atrial Fibrillation: Inflammation as a Common Pathophysiological Bridge.International journal of molecular sciences · 2026Review
- The Role of Major Inflammatory Biomarkers in the Pathogenesis of Atrial Fibrillation.The Journal of innovations in cardiac rhythm management · 2022Article
- Cardiac arrhythmias in arterial hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2020Review
- The serum matrix metalloproteinase-9 level is an independent predictor of recurrence after ablation of persistent atrial fibrillation.Clinics (Sao Paulo, Brazil) · 2016Article
- MMP9 Rs3918242 Polymorphism Affects Tachycardia-Induced MMP9 Expression in Cultured Atrial-Derived Myocytes but Is Not a Risk Factor for Atrial Fibrillation among the Taiwanese.International journal of molecular sciences · 2016Article
- Biomarkers in electrophysiology: role in arrhythmias and resynchronization therapy.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2015Article
- [Retroperitoneal fibrosis: development of a biomarker profile for diagnosis and therapy monitoring].Der Urologe. Ausg. A · 2015Article
- Novel fibro-inflammation markers in assessing left atrial remodeling in non-valvular atrial fibrillation.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Cardioembolic stroke diagnosis using blood biomarkers.Current cardiology reviews · 2013Review
- Article
- MMP-2 and sTNF-R1 Variability in Patients with Essential Hypertension: 1-Year Follow-Up Study.ISRN cardiology · 2012Article
- Circulating Biomarkers Predictive of Postoperative Atrial Fibrillation.Cardiology in reviewReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMatrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are essential for the cardiac extracellular matrix (ECM) remodeling. We investigated differences in serum levels of these markers between patients with atrial fibrillation (AF) and sinus rhythm (SR).
methodsSerum levels of MMP-2, MMP-3, MMP-9 and TIMP-1 were measured in 86 patients: 27 on SR without any AF history, 33 with paroxysmal and 26 with permanent AF. All subjects had essential hypertension, normal systolic function and no coronary artery disease.
resultsPatients with AF had higher MMP-2, MMP-3 and MMP-9 and lower TIMP-1 compared to SR subjects (all p < 0.001). Paroxysmal AF was associated with higher MMP-2 levels compared to permanent AF (p < 0.001). Matrix metalloproteinase-9 but not MMP-3 was higher in permanent compared to paroxysmal AF group (p < 0.001). Patients with AF had lower levels of TIMP-1 compared to those with SR while permanent AF subjects had lower TIMP-1 levels than those with paroxysmal AF (p < 0.001 for both comparisons). Lower TIMP-1 was the only independent factor associated with AF (OR: 0.259, 95%CI: 0.104-0.645, p = 0.004).
conclusionsIn hypertensives, paroxysmal AF and permanent AF differ with respect to serum MMPs. Increased MMP-2 is associated with paroxysmal, whereas increased MMP-9 with permanent AF. Additionally, lower levels of TIMP-1 had a strong association with AF incidence.
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