ArticleBMC genomics2011
Novel features of ARS selection in budding yeast Lachancea kluyveri.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Various short autonomously replicating sequences from the yeastCurrent research in microbial sciences · 2021Article
- Conservation of a DNA Replication Motif among Phylogenetically Distant Budding Yeast Species.Genome biology and evolution · 2021Article
- The evolution of the temporal program of genome replication.Nature communications · 2018Article
- DNA replication timing influences gene expression level.The Journal of cell biology · 2017Article
- Context based computational analysis and characterization of ARS consensus sequences (ACS) of Saccharomyces cerevisiae genome.Genomics data · 2016Article
- Genome-wide replication landscape of Candida glabrata.BMC biology · 2015Article
- Article
- An autonomously replicating sequence for use in a wide range of budding yeasts.FEMS yeast research · 2014Article
- GC-rich DNA elements enable replication origin activity in the methylotrophic yeast Pichia pastoris.PLoS genetics · 2014Article
- DNA replication origins.Cold Spring Harbor perspectives in biology · 2013Review
- High-resolution mapping, characterization, and optimization of autonomously replicating sequences in yeast.Genome research · 2013Article
- The spatiotemporal program of replication in the genome of Lachancea kluyveri.Genome biology and evolution · 2013Article
- Conservation of replication timing reveals global and local regulation of replication origin activity.Genome research · 2012Article
- Maintaining replication origins in the face of genomic change.Genome research · 2012Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe characterization of DNA replication origins in yeast has shed much light on the mechanisms of initiation of DNA replication. However, very little is known about the evolution of origins or the evolution of mechanisms through which origins are recognized by the initiation machinery. This lack of understanding is largely due to the vast evolutionary distances between model organisms in which origins have been examined.
resultsIn this study we have isolated and characterized autonomously replicating sequences (ARSs) in Lachancea kluyveri - a pre-whole genome duplication (WGD) budding yeast. Through a combination of experimental work and rigorous computational analysis, we show that L. kluyveri ARSs require a sequence that is similar but much longer than the ARS Consensus Sequence well defined in Saccharomyces cerevisiae. Moreover, compared with S. cerevisiae and K. lactis, the replication licensing machinery in L. kluyveri seems more tolerant to variations in the ARS sequence composition. It is able to initiate replication from almost all S. cerevisiae ARSs tested and most Kluyveromyces lactis ARSs. In contrast, only about half of the L. kluyveri ARSs function in S. cerevisiae and less than 10% function in K. lactis.
conclusionsOur findings demonstrate a replication initiation system with novel features and underscore the functional diversity within the budding yeasts. Furthermore, we have developed new approaches for analyzing biologically functional DNA sequences with ill-defined motifs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.