ArticleCardiovascular diabetology2011
Hyperglycemia in apolipoprotein E-deficient mouse strains with different atherosclerosis susceptibility.
Article in Cardiovascular diabetology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 43 citations in OpenAlex.
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- Cellular crosstalk in organotypic vasculature: mechanisms of diabetic cardiorenal complications and SGLT2i responses.Cardiovascular diabetology · 2025Article
- Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells.International journal of molecular sciences · 2024Article
- Deletion of Smooth Muscle O-GlcNAc Transferase Prevents Development of Atherosclerosis in Western Diet-Fed Hyperglycemic ApoEInternational journal of molecular sciences · 2023Article
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- The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization.Nature communications · 2022Article
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- Genetic Evidence for a Causal Relationship between Hyperlipidemia and Type 2 Diabetes in Mice.International journal of molecular sciences · 2022Article
- Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice.Genes · 2022Article
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- Prenylcysteine oxidase 1, an emerging player in atherosclerosis.Communications biology · 2021Article
- Hyperlipidemia Influences the Accuracy of Glucometer-Measured Blood Glucose Concentrations in Genetically Diverse Mice.The American journal of the medical sciences · 2021Article
- The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review.Molecules (Basel, Switzerland) · 2021Review
- Inflammation and enhanced atherogenesis in the carotid artery with altered blood flow in an atherosclerosis-resistant mouse strain.Physiological reports · 2021Article
- Phosphoproteomic Analysis of Subcutaneous and Omental Adipose Tissue Reveals Increased Lipid Turnover in Dairy Cows Supplemented with Conjugated Linoleic Acid.International journal of molecular sciences · 2021Article
- Atherogenesis in the Carotid Artery with and without Interrupted Blood Flow of Two Hyperlipidemic Mouse Strains.Journal of vascular research · 2019Article
- Canagliflozin attenuates the progression of atherosclerosis and inflammation process in APOE knockout mice.Cardiovascular diabetology · 2018Article
- Accelerated atherogenesis in completely ligated common carotid artery of apolipoprotein E-deficient mice.Oncotarget · 2017Article
- Lysophosphatidic acid-induced vascular neointimal formation in mouse carotid arteries is mediated by the matricellular protein CCN1/Cyr61.American journal of physiology. Cell physiology · 2016Article
- The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells.Redox biology · 2016Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundType 2 diabetes mellitus (T2DM) is associated with an increased risk of atherosclerotic vascular disease, but it is unknown whether the other way around is true too. C57BL/6 (B6) and BALB/cJ (BALB) are two mouse strains that differ markedly in their susceptibility to atherosclerosis. In this study we investigated the development of diet-induced T2DM in these two strains. METHODS AND
resultsWhen deficient in apolipoprotein E (apoE(-/-)) and fed a Western diet for 12 weeks, atherosclerosis-susceptible B6 mice developed significant hyperglycemia. In contrast, atherosclerosis-resistant BALB apoE(-/-) mice had much lower plasma glucose levels than B6.apoE(-/-) mice on either chow or Western diet and during an intraperitoneal glucose tolerance test. In response to glucose BALB.apoE(-/-) mice displayed both the first and second phases of insulin secretion but the second phase of insulin secretion was absent in B6.apoE(-/-) mice. In response to insulin B6.apoE(-/-) mice showed a deeper and longer-lasting fall in blood glucose levels while BALB.apoE(-/-) mice showed little reduction in glucose levels. Pancreatic islet area of BALB.apoE(-/-) mice on light microscopy nearly doubled the area of B6.apoE(-/-) mice. Most circulating proinflammatory cytokines were lower in BALB.apoE(-/-) than in B6.apoE(-/-) mice on the Western diet, as determined by protein arrays. Increased macrophage infiltration in islets was observed in B6.apoE(-/-) mice by immunostaining for Mac2 and also by flow cytometry.
conclusionThis study demonstrates that defects in insulin secretion rather than defects in insulin resistance explain the marketed difference in susceptibility to T2DM in the B6.apoE(-/-) and BALB.apoE(-/-) mouse model. A smaller islet mass and more prominent islet inflammation may explain the vulnerability of B6.apoE(-/-) mice to diet-induced diabetes.
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