ArticleStem cells and development2012
Interordinal chimera formation between medaka and zebrafish for analyzing stem cell differentiation.
Article in Stem cells and development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Characterizing Marine Medaka (Animals : an open access journal from MDPI · 2024Article
- The Multi-Causal Basis of Developmental Potential Construction.Acta biotheoretica · 2023Article
- Article
- Does resource availability help determine the evolutionary route to multicellularity?Evolution & development · 2019Article
- Germline replacement by blastula cell transplantation in the fish medaka.Scientific reports · 2016Article
- Dazl is a critical player for primordial germ cell formation in medaka.Scientific reports · 2016Article
- Dnd Is a Critical Specifier of Primordial Germ Cells in the Medaka Fish.Stem cell reports · 2016Article
- Medaka Oct4 is essential for pluripotency in blastula formation and ES cell derivation.Stem cell reviews and reports · 2015Article
- Gene transfer and genome-wide insertional mutagenesis by retroviral transduction in fish stem cells.PloS one · 2015Article
- Derivation and long-term culture of an embryonic stem cell-like line from zebrafish blastomeres under feeder-free condition.Zebrafish · 2014Article
- Article
- Nanos3 gene targeting in medaka ES cells.International journal of biological sciences · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chimera formation is a standard test for pluripotency of stem cells in vivo. Interspecific chimera formation between distantly related organisms offers also an attractive approach for propagating endangered species. Parameters influencing interspecies chimera formation have remained poorly elucidated. Here, we report interordinal chimera formation between medaka and zebrafish, which separated ∼320 million years ago and exhibit a more than 2-fold difference in developmental speed. We show that, on transplantation into zebrafish blastulae, both noncultivated blastomeres and long-term cultivated embryonic stem (ES) cells of medaka adopted the zebrafish developmental program and differentiated into physiologically functional cell types including pigment cells, blood cells, and cardiomyocytes. We also show that medaka ES cells express differentiation gene markers during chimeric embryogenesis. Therefore, the evolutionary distance and different embryogenesis speeds do not produce donor-host incompatibility to compromise chimera formation between medaka and zebrafish, and molecular markers are valuable for analyzing lineage commitment and cell differentiation in interspecific chimeric embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.