Evidence map›Paper›PMID 22204448›Full record

ArticleBMC pediatrics2011

The effect of systematic pediatric care on neonatal mortality and hospitalizations of infants born with oral clefts.

George L Wehby, Eduardo E Castilla, Norman Goco, Monica Rittler, Viviana Cosentino, Lorette Javois, Mark Kindem, Hrishikesh Chakraborty, Graca Dutra, Jorge S López-Camelo and 2 more

Registry-linked trialOpen access · goldAbstract readControlled Clinical Trial
In one paragraph

Article in BMC pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00097149 (Systematic Pediatric Care for Oral Clefts - South America), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00097149 nacompletednot on this map

Systematic Pediatric Care for Oral Clefts - South America

TypeinterventionalSponsorNICHD Global Network for Women's and Children's HealthRan2003 to 2006Enrolled696ConditionsCleft Lip, Cleft Palate, Congenital DefectsArmsSystematic pediatric care
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Long-term effects of oral clefts on health care utilization: a sibling comparison.The European journal of health economics : HEPAC : health economics in prevention and care · 2015
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

George L WehbyDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Eduardo E Castilla
Norman Goco
Monica Rittler
Viviana Cosentino
Lorette Javois
Mark Kindem
Hrishikesh Chakraborty
Graca Dutra
Jorge S López-Camelo
Iêda M Orioli
Jeffrey C Murray
National Institute on Population Medical Genetics · BRRTI International · USUniversity of Iowa · USCentro de Educación Médica e Investigaciones Clínicas Norberto Quirno · AREstudios Clínicos Latinoamérica · AREunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversidade Federal do Rio de Janeiro · BRUniversity of South Carolina · US

Funding

Molecular Genetic Epidemiology of Cleft Lip and PalateR37DE008559 · NIDCR · UNIVERSITY OF IOWA · PI MURRAY, JEFFREY C · 2004 to 2013
$6.8M
Health outcomes and improved phenotypic characterization of cleft lip and palateR01DD000295 · DD · UNIVERSITY OF IOWA · PI WEHBY, GEORGE L · 2007 to 2009
$1.4M
Effects of oral clefts on birth outcomes and cleft risks due to maternal smokingR03DE018394 · NIDCR · UNIVERSITY OF IOWA · PI WEHBY, GEORGE L · 2007 to 2008
$295k
NCBDD CDC HHS 1R01DD000295NICHD NIH HHS U01HD04056NIDCR NIH HHS 1 R03 DE018394NIDCR NIH HHS R37 DE008559NIDCR NIH HHS R37 DE08559
6 · The paper itself

Abstract

backgroundCleft lip and/or palate (CL/P) increase mortality and morbidity risks for affected infants especially in less developed countries. This study aimed at assessing the effects of systematic pediatric care on neonatal mortality and hospitalizations of infants with cleft lip and/or palate (CL/P) in South America.

methodsThe intervention group included live-born infants with isolated or associated CL/P in 47 hospitals between 2003 and 2005. The control group included live-born infants with CL/P between 2001 and 2002 in the same hospitals. The intervention group received systematic pediatric care between the 7th and 28th day of life. The primary outcomes were mortality between the 7th and 28th day of life and hospitalization days in this period among survivors adjusted for relevant baseline covariates.

resultsThere were no significant mortality differences between the intervention and control groups. However, surviving infants with associated CL/P in the intervention group had fewer hospitalization days by about six days compared to the associated control group.

conclusionsEarly systematic pediatric care may significantly reduce neonatal hospitalizations of infants with CL/P and additional birth defects in South America. Given the large healthcare and financial burden of CL/P on affected families and the relatively low cost of systematic pediatric care, improving access to such care may be a cost-effective public policy intervention.

trial registrationClinicalTrials.gov: NCT00097149.

Indexed as

Infant CareInfant MortalityCleft LipCleft PalateFemaleHospitalizationHumansInfantLogistic ModelsMalePediatricsSouth America

Identifiers

PMID22204448
PMCPMC3277464
OpenAlexW1972983399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.