ReviewOmics : a journal of integrative biology
Apoptotic signaling in mouse odontogenesis.
Review in Omics : a journal of integrative biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Metabolic programming in tooth development: a regulatory network from energy substrates to signaling instructions.Frontiers in cell and developmental biology · 2026Review
- The role of autophagy in odontogenesis, dental implant surgery, periapical and periodontal diseases.Journal of cellular and molecular medicine · 2024Review
- FasL Is Required for Osseous Healing in Extraction Sockets in Mice.Frontiers in immunology · 2021Article
- Squamate egg tooth development revisited using three-dimensional reconstructions of brown anole (Anolis sagrei, Squamata, Dactyloidae) dentition.Journal of anatomy · 2020Article
- Activation of Pro-apoptotic Caspases in Non-apoptotic Cells During Odontogenesis and Related Osteogenesis.Frontiers in physiology · 2018Article
- Bcl-2 expression is essential for development and normal physiological properties of tooth hard tissue and saliva production.Experimental cell research · 2017Article
- Caspases and osteogenic markers--in vitro screening of inhibition impact.In vitro cellular & developmental biology. Animal · 2016Article
- Developmental mechanisms underlying differential claw expression in the autopodia of geckos.EvoDevo · 2015Article
- Localization of Beclin1 in mouse developing tooth germs: possible implication of the interrelation between autophagy and apoptosis.Journal of molecular histology · 2013Article
- Autophagy appears during the development of the mouse lower first molar.Histochemistry and cell biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apoptosis is an important morphogenetic event in embryogenesis as well as during postnatal life. In the last 2 decades, apoptosis in tooth development (odontogenesis) has been investigated with gradually increasing focus on the mechanisms and signaling pathways involved. The molecular machinery responsible for apoptosis exhibits a high degree of conservation but also organ and tissue specific patterns. This review aims to discuss recent knowledge about apoptotic signaling networks during odontogenesis, concentrating on the mouse, which is often used as a model organism for human dentistry. Apoptosis accompanies the entire development of the tooth and corresponding remodeling of the surrounding bony tissue. It is most evident in its role in the elimination of signaling centers within developing teeth, removal of vestigal tooth germs, and in odontoblast and ameloblast organization during tooth mineralization. Dental apoptosis is caspase dependent and proceeds via mitochondrial mediated cell death with possible amplification by Fas-FasL signaling modulated by Bcl-2 family members.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.