ArticleEvidence-based complementary and alternative medicine : eCAM2012
A systematic review of the effect of expectancy on treatment responses to acupuncture.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Expectancy Effect of Acupuncture on Cancer-Related Outcomes: A Systematic Review.Oncology nursing forum · 2024Pooled it
- The effectiveness and safety of acupuncture for poor semen quality in infertile males: a systematic review and meta-analysis.Asian journal of andrologyPooled it
- Acupuncture for acute treatment of migraine without aura: A randomized clinical trial.Headache · 2026Trial
- Does expectancy affect insomnia treatment response in cancer survivors receiving acupuncture and cognitive behavioral therapy?Journal of cancer survivorship : research and practice · 2023Trial
- Acupuncture for the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome: A Pilot Randomized Clinical Trial.JAMA network open · 2022Trial
- Trial
- Trial
- Placebo by proxy expectations toward acupuncture change over time: a survey comparing parental expectations to acupuncture pre- and postoperatively.BMC complementary and alternative medicine · 2018Trial
- Electroacupuncture and splinting versus splinting alone to treat carpal tunnel syndrome: a randomized controlled trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Trial
- Prior experience with a pain stimulus as a predictor of placebo analgesia.Journal of behavioral medicine · 2015Trial
- Expectancy in real and sham electroacupuncture: does believing make it so?Journal of the National Cancer Institute. Monographs · 2014Trial
- Trial
- Impact of Baseline Expectancy on Outcome Prediction of Real and Sham Acupuncture for Persistent Chemotherapy-Induced Peripheral Neuropathy Pain in Solid Tumor Survivors: A Secondary Analysis of a Randomized Clinical Trial.Integrative cancer therapiesTrial
- An innovative acupuncture treatment for primary dysmenorrhea: a randomized, crossover pilot study.Alternative therapies in health and medicineTrial
- Understanding Placebo and Nocebo Responses Based on a Randomized Sham-Controlled Study on Acupuncture in Integrative Cancer Care.Integrative cancer therapiesTrial
- Acupuncture for premature ovarian insufficiency: a systemic neuroendocrine perspective.Frontiers in endocrinology · 2026Review
- Methodological Considerations in Combined Pudendal Nerve Block and Wrist-Ankle Acupuncture for Postoperative Analgesia After Perianal Abscess Surgery [Letter].Journal of pain research · 2026Article
- Why some embrace and others hesitate? A behavioral analysis of insomnia sufferers' engagement with acupuncture treatment.World journal of psychiatry · 2025Article
- How does pretreatment expectancy influence pain outcomes with electroacupuncture and battlefield acupuncture in cancer survivors?: Pretreatment expectancy and pain reduction by acupuncture.Integrative medicine research · 2024Article
- Temporal summation does not predict the acupuncture response in patients with chronic non-specific low back pain.Frontiers in neurology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Randomised controlled trials (RCTs) of acupuncture often find equivalent responses to real and placebo acupuncture despite both appearing superior to no treatment. This raises questions regarding the mechanisms of acupuncture, especially the contribution of patient expectancies. We systematically reviewed previous research assessing the relationship between expectancy and treatment responses following acupuncture, whether real or placebo. To be included, studies needed to assess and/or manipulate expectancies about acupuncture and relate these to at least one health-relevant outcome. Nine such independent studies were identified through systematic searches of Medline, PsycInfo, PubMed, and Cochrane Clinical Trials Register. The methodology and reporting of these studies were quite heterogeneous, meaning that meta-analysis was not possible. A descriptive review revealed that five studies found statistically significant effects of expectancy on a least one outcome, with three also finding evidence suggestive of an interaction between expectancy and type of acupuncture (real or placebo). While there were some trends in significant effects in terms of study characteristics, their generality is limited by the heterogeneity of study designs. The differences in design across studies highlight some important methodological considerations for future research in this area, particularly regarding whether to assess or manipulate expectancies and how best to assess expectancies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.