ArticleEvidence-based complementary and alternative medicine : eCAM2012
Induction of Mitochondria-Mediated Apoptosis in Ca Ski Human Cervical Cancer Cells Triggered by Mollic Acid Arabinoside Isolated from Leea indica.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Effects of Leea indica leaf extracts and its phytoconstituents on natural killer cell-mediated cytotoxicity in human ovarian cancer.BMC complementary medicine and therapies · 2023Article
- Anti-Inflammatory, Thrombolytic and Hair-Growth Promoting Activity of thePlants (Basel, Switzerland) · 2021Article
- Piperazine ferulate attenuates high glucose‑induced mesangial cell injury via the regulation of p66Molecular medicine reports · 2021Article
- Assessment of the Role of Noni (International journal of stem cells · 2016Article
- Apoptotic potential role of Agave palmeri and Tulbaghia violacea extracts in cervical cancer cells.Molecular biology reports · 2014Article
- Antioxidative, antimicrobial and cytotoxic effects of the phenolics of Leea indica leaf extract.Saudi journal of biological sciences · 2013Article
- Phenolic content, antioxidant effect and cytotoxic activity of Leea indica leaves.BMC complementary and alternative medicine · 2012Article
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Abstract
Leea indica is a medicinal plant traditionally used to treat cancer. Through bioassay-guided approach, we isolated mollic acid arabinoside (MAA), for the first time from Leea indica. Here, we present the apoptosis-inducing effect of MAA on Ca Ski cervical cancer cells. Based on DAPI staining, MAA-treated cells manifested nuclear shrinkage, condensation, and fragmentation. We further confirmed the fragmentation of DNA using TUNEL assay. During early apoptosis, MAA caused the perturbation of plasma membrane through externalization of PS, followed by the formation of apoptotic blebs. Prior to these events, MAA triggered rapid dissipation of the mitochondrial membrane potential. In the upstream, MAA increased the expression of Bax, decreased the expression of Bcl-2, and augmented the Bax/Bcl-2 ratio. These findings suggested that MAA induced mitochondrial-mediated apoptosis in Ca Ski cells and thus provide the scientific explanation for the traditional application of this herbal medicine in cancer treatment.
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