ArticleEvidence-based complementary and alternative medicine : eCAM2012
Ixora parviflora Protects against UVB-Induced Photoaging by Inhibiting the Expression of MMPs, MAP Kinases, and COX-2 and by Promoting Type I Procollagen Synthesis.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05390489 (Effect of Arabica Coffee), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Arabica Coffee (Coffea Arabica) Cascara Pulp Extract From Gayo as Topical Antioxidant in the Treatment of Photoaging
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Curcumin: a potential anti-photoaging agent.Frontiers in pharmacology · 2025Review
- Mechanisms and Therapeutic Roles of Medicinal Plants in Skin Photoaging.Clinical, cosmetic and investigational dermatology · 2025Review
- Dieckol Isolated fromMarine drugs · 2022Article
- Anti-Aging Effect and Mechanism of Proanthocyanidins Extracted fromAntioxidants (Basel, Switzerland) · 2022Article
- Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin.Antioxidants (Basel, Switzerland) · 2021Article
- Protective Activity and Underlying Mechanism of Ginseng Seeds against UVB-Induced Damage in Human Fibroblasts.Antioxidants (Basel, Switzerland) · 2021Article
- Anti-photoaging activities ofCytotechnology · 2021Article
- Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance.Pharmaceutics · 2020Review
- Penta-1,2,3,4,6-Antioxidants (Basel, Switzerland) · 2019Article
- Article
- Protective Effects and Mechanisms ofInternational journal of molecular sciences · 2019Article
- Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study.Scientific reports · 2018Article
- The Red Algae Compound 3-Bromo-4,5-dihydroxybenzaldehyde Protects Human Keratinocytes on Oxidative Stress-Related Molecules and Pathways Activated by UVB Irradiation.Marine drugs · 2017Article
- Antiinflammatory and Antiphotodamaging Effects of Ergostatrien-3β-ol, Isolated from Antrodia camphorata, on Hairless Mouse Skin.Molecules (Basel, Switzerland) · 2016Article
- Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis.International journal of molecular sciences · 2016Review
- Rhodiola plants: Chemistry and biological activity.Journal of food and drug analysis · 2015Review
- In Vitro and In Vivo Studies on Protective Action of N-Phenethyl Caffeamide against Photodamage of Skin.PloS one · 2015Article
- Hepatoprotective effects of Ixora parviflora extract against exhaustive exercise-induced oxidative stress in mice.Molecules (Basel, Switzerland) · 2013Article
- Neonauclea reticulata (Havil.) Merr Stimulates Skin Regeneration after UVB Exposure via ROS Scavenging and Modulation of the MAPK/MMPs/Collagen Pathway.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Skin ageing: natural weapons and strategies.Evidence-based complementary and alternative medicine : eCAM · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ixora parviflora with high polyphenol content exhibited antioxidant activity and reducing UVB-induced intracellular reactive oxygen species production. In this study, results of the photoaging screening experiments revealed that IPE at 1000 μg/mL reduced the activity of bacterial collagenase by 92.7 ± 4.2% and reduced the activity of elastase by 32.6 ± 1.4%. Therefore, we investigated the mechanisms by which IPE exerts its anti-photoaging activity. IPE at 1 μg/mL led to an increase in type I procollagen expression and increased total collagen synthesis in fibroblasts at 5 μg/mL. We found that IPE inhibited MMP-1, MMP-3, and MMP-9 expression at doses of 1, 5, and 10 μg/mL, respectively, in fibroblasts exposed to UV irradiation (40 mJ/cm(2)). Gelatin zymography assay showed that IPE at 50 μg/mL inhibited MMP-9 secretion/activity in cultured fibroblasts after UVB exposure. In addition, IPE inhibited the phosphorylation of p38, ERK, and JNK induced by UVB. Furthermore, IPE inhibited the UVB-induced expression of Smad7. In addition, IPE at 1 μg/mL inhibited NO production and COX-2 expression in UV-exposed fibroblasts. These findings show that IPE exhibits anti-inflammatory and anti-photoaging activities, indicating that IPE could be a potential anti-aging agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.