ArticleEvidence-based complementary and alternative medicine : eCAM2012
Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
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- Neurite Outgrowth-Promoting Compounds from the Petals ofMolecules (Basel, Switzerland) · 2022Article
- Neurotrophic and Immunomodulatory Lanostane Triterpenoids from Wood-Inhabiting Basidiomycota.International journal of molecular sciences · 2022Article
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- The Neurotrophic-Like Effect of Carvacrol: Perspective for Axonal and Synaptic Regeneration.Neurotoxicity research · 2021Article
- Nutritional and 13-Week Subchronic Toxicological Evaluation ofInternational journal of environmental research and public health · 2021Article
- Anacardium Occidentale L. Leaf Extracts Protect Against Glutamate/HFrontiers in pharmacology · 2021Article
- HIV-1 protease and reverse transcriptase inhibition by tiger milk mushroom (Journal of traditional and complementary medicine · 2020Article
- Anti-viral activity of culinary and medicinal mushroom extracts against dengue virus serotype 2: an in-vitro study.BMC complementary and alternative medicine · 2019Article
- Human Embryonic Stem Cell-Derived Neural Lineages asBioMed research international · 2019Article
- Inhibition of Protein Glycation by Tiger Milk Mushroom [Frontiers in pharmacology · 2018Article
- A novel method of neural differentiation of PC12 cells by using Opti-MEM as a basic induction medium.International journal of molecular medicine · 2018Article
- The potential neuritogenic activity of aqueous extracts fromFood science and biotechnology · 2017Article
- A Status Review of the Bioactive Activities of Tiger Milk MushroomFrontiers in pharmacology · 2017Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A national treasure mushroom, Lignosus rhinocerus, has been used to treat variety of ailments by local and indigenous communities in Malaysia. The aim of this study was to investigate the potential of the most valuable part of L. rhinocerus, the sclerotium, on neurite outgrowth activity by using PC-12Adh cell line. Differentiated cells with one thin extension at least double the length of the cell diameter were scored positive. Our results showed that aqueous sclerotium L. rhinocerus extract induced neurite outgrowths of 24.4% and 42.1% at 20 μg/mL (w/v) of aqueous extract alone and a combination of 20 μg/mL (w/v) aqueous extract and 30 ng/mL (w/v) of NGF, respectively. Combination of NGF and sclerotium extract had additive effects and enhanced neurite outgrowth. Neuronal differentiation was demonstrated by indirect immunofluorescence of neurofilament protein. Aqueous sclerotium extract contained neuroactive compounds that stimulated neurite outgrowth in vitro. To our knowledge this is the first report on neurite-stimulating activities of L. rhinocerus.
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Registered trials
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