ArticleEvidence-based complementary and alternative medicine : eCAM2012
Bioassay-Guided Isolation of Cytotoxic Cycloartane Triterpenoid Glycosides from the Traditionally Used Medicinal Plant Leea indica.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- An ethnobotanical review of medicinal plants used for treating hemorrhoids in Thailand.Frontiers in pharmacology · 2026Pooled it
- Antiproliferative activities of some selected Nigerian medicinal plants against breast, liver, and cervical cancer cells.BMC complementary medicine and therapies · 2024Article
- Apoptosis-inducing anti-proliferative and quantitative phytochemical profiling with in silico study of antioxidant-richHeliyon · 2024Article
- Natural Gallic Acid and Methyl Gallate Induces Apoptosis in Hela Cells through Regulation of Intrinsic and Extrinsic Protein Expression.International journal of molecular sciences · 2023Article
- Effects of Leea indica leaf extracts and its phytoconstituents on natural killer cell-mediated cytotoxicity in human ovarian cancer.BMC complementary medicine and therapies · 2023Article
- BACE1: A Key Regulator in Alzheimer's Disease Progression and Current Development of its Inhibitors.Current neuropharmacology · 2022Review
- GC-MS Analysis of Potentially Volatile Compounds ofFrontiers in microbiology · 2022Article
- Anti-Inflammatory, Thrombolytic and Hair-Growth Promoting Activity of thePlants (Basel, Switzerland) · 2021Article
- Anticarcinogenic and Antioxidant Action of an Edible Aquatic FloraMolecules (Basel, Switzerland) · 2021Article
- Traditional uses and pharmacological activities of the genus leea and its phytochemicals: A review.Heliyon · 2021Review
- Cytotoxic and cell cycle arrest properties of two steroidal alkaloids isolated from Holarrhena floribunda (G. Don) T. Durand & Schinz leaves.BMC complementary and alternative medicine · 2019Article
- Phytochemical Study of Aerial Parts ofMolecules (Basel, Switzerland) · 2019Article
- Identification of Phytoconstituents inMolecules (Basel, Switzerland) · 2019Article
- In vitro cytotoxic activity of medicinal plants from Nigeria ethnomedicine on Rhabdomyosarcoma cancer cell line and HPLC analysis of active extracts.BMC complementary and alternative medicine · 2017Article
- Review
- Argentatin B Inhibits Proliferation of Prostate and Colon Cancer Cells by Inducing Cell Senescence.Molecules (Basel, Switzerland) · 2015Article
- Article
- Phenolic content, antioxidant effect and cytotoxic activity of Leea indica leaves.BMC complementary and alternative medicine · 2012Article
- Induction of Mitochondria-Mediated Apoptosis in Ca Ski Human Cervical Cancer Cells Triggered by Mollic Acid Arabinoside Isolated from Leea indica.Evidence-based complementary and alternative medicine : eCAM · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leea indica is a medicinal plant used traditionally to cure cancer. In this study, the cytotoxic compounds of L. indica were isolated using bioassay-guided approach. Two cycloartane triterpenoid glycosides, mollic acid arabinoside (MAA) and mollic acid xyloside (MAX), were firstly isolated from L. indica. They inhibited the growth of Ca Ski cervical cancer cells with IC(50) of 19.21 μM (MAA) and 33.33 μM (MAX). MRC5 normal cell line was used to calculate selectivity index. MAA and MAX were about 8 and 4 times more cytotoxic to Ca Ski cells compared to MRC5. The cytotoxicity of MAA was characterized by both cytostatic and cytocidal effects. MAA decreased the expression of proliferative cell nuclear antigen, increased sub-G1 cells, and arrested cells in S and G2/M phases. This study provides the evidence for the ethnomedicinal use of L. indica and paves the way for future mechanism studies on the anticancer effects of MAA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.