ArticleClinical & developmental immunology2012
Development of murine hepatic NK cells during ontogeny: comparison with spleen NK cells.
Article in Clinical & developmental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Targeting Decidual CD16Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.Nature communications · 2023Article
- Understanding, predicting and achieving liver transplant tolerance: from bench to bedside.Nature reviews. Gastroenterology & hepatology · 2020Review
- Key features and homing properties of NK cells in the liver are shaped by activated iNKT cells.Scientific reports · 2019Article
- Murine CMV Expressing the High Affinity NKG2D Ligand MULT-1: A Model for the Development of Cytomegalovirus-Based Vaccines.Frontiers in immunology · 2018Article
- NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis.Scientific reports · 2017Article
- NK Cell Subtypes as Regulators of Autoimmune Liver Disease.Gastroenterology research and practice · 2016Review
- NK cell trafficking in health and autoimmunity:a comprehensive review.Clinical reviews in allergy & immunology · 2014Review
- The porcine innate immune system: an update.Developmental and comparative immunology · 2014Review
- Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice.PloS one · 2014Article
- Multiple levels of chemokine receptor regulation in the control of mouse natural killer cell development.Frontiers in immunology · 2014Review
- Memory NK cells: why do they reside in the liver?Cellular & molecular immunology · 2013Review
- Nodular inflammatory foci are sites of T cell priming and control of murine cytomegalovirus infection in the neonatal lung.PLoS pathogens · 2013Article
- Analysis of cell surface markers specific for transplantable rod photoreceptors.Molecular vision · 2013Article
- Article
- The suckling rat as a model for immunonutrition studies in early life.Clinical & developmental immunology · 2012Review
- Immune responses to congenital cytomegalovirus infection.Microbes and infectionReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenotype of developing liver NK cells (CD3(-)NK1.1(+)) was investigated during mouse ontogeny comparing with spleen NK cells. The highest percentage of hepatic CD27(-)CD11b(-) NK cells occurred at the fetal stage. After birth, the percentage of CD27(-)CD11b(-)NK cells in both the liver and spleen gradually decreased to their lowest level at 6 weeks. More CD27(+)CD11b(-)NK cells were detected in the liver than that in spleen from week 1 to 6. Expression of NKG2A on liver NK cells was decreased but still much higher than that of spleen NK cells after 1 week. The NKG2D expression on liver NK cells increased to its highest level and was significantly higher than on spleen NK cells till 4 weeks. During mouse ontogeny, weaker expression of NKp46 and CD2 and stronger expression of CD69, CD11c, 2B4, and CD73 were observed on liver NK cells. Furthermore, neonatal liver NK cells express higher IFN-γ and perforin than adult .These results suggest that the maturation process of NK cells is unique in the livers, and liver microenvironments might play critical roles to keep NK cells in an immature status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.