ArticleCase reports in medicine2011
Resistance exercise reduces skeletal muscle cachexia and improves muscle function in rheumatoid arthritis.
Article in Case reports in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Trial
- Mechanical Stimulation of Adhesion Receptors Using Light-Responsive Nanoparticle Actuators Enhances Myogenesis.ACS applied materials & interfaces · 2020Article
- Article
- Chronic Inflammation in Rheumatoid Arthritis and Mediators of Skeletal Muscle Pathology and Physical Impairment: A Review.Arthritis care & research · 2019Review
- Inflammatory signalling regulates eccentric contraction-induced protein synthesis in cachectic skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2018Article
- Home Exercise Training Improves Exercise Capacity in Cirrhosis Patients: Role of Exercise Adherence.Scientific reports · 2018Article
- Decreasing muscle performance associated with increasing disease activity in patients with rheumatoid arthritis.PloS one · 2018Article
- Muscle Weakness in Rheumatoid Arthritis: The Role of CaEBioMedicine · 2017Review
- Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation.Nature reviews. Rheumatology · 2015Review
- Rheumatoid cachexia revisited: a metabolic co-morbidity in rheumatoid arthritis.Frontiers in nutrition · 2014Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune, inflammatory disease associated with cachexia (reduced muscle and increased fat). Although strength-training exercise has been used in persons with RA, it is not clear if it is effective for reducing cachexia. A 46-year-old woman was studied to determine: (i) if resistance exercise could reverse cachexia by improving muscle mass, fiber cross-sectional area, and muscle function; and (2) if elevated apoptotic signaling was involved in cachexia with RA and could be reduced by resistance training. A needle biopsy was obtained from the vastus lateralis muscle of the RA subject before and after 16 weeks of resistance training. Knee extensor strength increased by 13.6% and fatigue decreased by 2.8% Muscle mass increased by 2.1%. Average muscle fiber cross-sectional area increased by 49.7%, and muscle nuclei increased slightly after strength training from 0.08 to 0.12 nuclei/μm(2). In addition, there was a slight decrease (1.6%) in the number of apoptotic muscle nuclei after resistance training. This case study suggests that resistance training may be a good tool for increasing the number of nuclei per fiber area, decreasing apoptotic nuclei, and inducing fiber hypertrophy in persons with RA, thereby slowing or reversing rheumatoid cachexia.
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Registered trials
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