ReviewExperimental diabetes research2012
Endoplasmic reticulum stress-related factors protect against diabetic retinopathy.
Review in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Dysfunction of the Neurovascular Unit in Diabetic Retinopathy: Advances from Molecular Mechanisms to Targeted Interventions.Stem cell reviews and reports · 2026Review
- Diosmetin Restores Endoplasmic Reticulum Homeostasis to Ameliorate Podocyte Injury in Diabetic Kidney Disease by Targeting DNAJC3.Journal of diabetes research · 2026Article
- Investigation of endoplasmic reticulum stress parameters in patients with gestational diabetes mellitus: A prospective study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Identification of immune-related endoplasmic reticulum stress genes in proliferative diabetic retinopathy using bioinformatics analysis.Frontiers in endocrinology · 2024Article
- SRY-box transcription factor 9 modulates Müller cell gliosis in diabetic retinopathy by upregulating TXNIP transcription.Experimental animals · 2023Article
- ER stress and unfolded protein response in ocular health and disease.The FEBS journal · 2019Review
- Lycium Barbarum Polysaccharides Improve Retinopathy in Diabetic Sprague-Dawley Rats.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy.Drug design, development and therapy · 2018Article
- Ursodeoxycholic Acid Attenuates Endoplasmic Reticulum Stress-Related Retinal Pericyte Loss in Streptozotocin-Induced Diabetic Mice.Journal of diabetes research · 2017Article
- Overexpression of p58ipk protects neuroblastoma against paraquat-induced toxicity.International journal of clinical and experimental pathology · 2017Article
- Grape seed proanthocyanidin extract protects the retina against early diabetic injury by activating the Nrf2 pathway.Experimental and therapeutic medicine · 2016Article
- Experimental study of the protective effects of SYVN1 against diabetic retinopathy.Scientific reports · 2015Article
- The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding.Progress in retinal and eye research · 2015Review
- Regulated inositol-requiring protein 1-dependent decay as a mechanism of corin RNA and protein deficiency in advanced human systolic heart failure.Journal of the American Heart Association · 2014Article
- Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic death.Journal of molecular neuroscience : MN · 2014Article
- Article
- Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy.Neural regeneration research · 2013Article
- Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.The American journal of pathology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endoplasmic reticulum (ER) is a principal mediator of signal transduction in the cell, and disruption of its normal function (a mechanism known as ER stress) has been associated with the pathogenesis of several diseases. ER stress has been demonstrated to contribute to onset and progression of diabetic retinopathy (DR) by induction of multiple inflammatory signaling pathways. Recent studies have begun to describe the gene expression profile of ER stress-related genes in DR; moreover, genes that play a protective role against DR have been identified. P58(IPK) was determined to be able to reduce retinal vascular leakage under high glucose conditions, thus protecting retinal cells. It has also been found by our lab that ER-associated protein degradation factors exhibit significantly different expression patterns in rat retinas under sustained high glucose conditions. Future research based upon these collective genomic findings will contribute to our overall understanding of DR pathogenesis as well as identify potential therapeutic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.