ArticleDementia and geriatric cognitive disorders extra2011
Long latency and high variability in accuracy-speed of prosaccades in Alzheimer's disease at mild to moderate stage.
Article in Dementia and geriatric cognitive disorders extra, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The application of saccades to assess cognitive impairment among older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Saccadic Eye Movement in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis.Neuropsychology review · 2022Pooled it
- Prosaccade and Antisaccade Paradigms in Persons with Alzheimer's Disease: A Meta-Analytic Review.Neuropsychology review · 2018Pooled it
- The Association between Saccadic Eye Movement Parameters and Mild Cognitive Impairment: The Nagahama Study.Ophthalmology science · 2026Article
- Simultaneous Analysis of Microsaccades and Pupil Size Variations in Age-Related Cognitive Impairment Using Eye-Tracking Technology.Journal of eye movement research · 2026Article
- The link between eye movements and cognitive function in mild to moderate Alzheimer's disease.Experimental brain research · 2025Article
- Eye movement abnormalities in Alzheimer's disease and other neurodegenerative dementias: insights from current evidence and priorities for future research.Frontiers in ophthalmology · 2025Review
- Eye Movement Latency Coefficient of Variation as a Predictor of Cognitive Impairment: An Eye Tracking Study of Cognitive Impairment.Vision (Basel, Switzerland) · 2023Article
- Visual attention during seeing for speaking in healthy aging.Psychology and aging · 2023Article
- Antisaccadic eye movements in middle-aged individuals with a family history of Alzheimer's disease.Frontiers in human neuroscience · 2023Article
- Afferent and Efferent Visual Markers of Alzheimer's Disease: A Review and Update in Early Stage Disease.Frontiers in aging neuroscience · 2020Article
- Novel Method for Rapid Assessment of Cognitive Impairment Using High-Performance Eye-Tracking Technology.Scientific reports · 2019Article
- Digital biomarkers for Alzheimer's disease: the mobile/ wearable devices opportunity.NPJ digital medicine · 2019Article
- MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice.International journal of molecular medicine · 2019Article
- Computational Techniques for Eye Movements Analysis towards Supporting Early Diagnosis of Alzheimer's Disease: A Review.Computational and mathematical methods in medicine · 2018Review
- Eyetracking Metrics in Young Onset Alzheimer's Disease: A Window into Cognitive Visual Functions.Frontiers in neurology · 2017Article
- Objective Evaluation of Vergence Disorders and a Research-Based Novel Method for Vergence Rehabilitation.Translational vision science & technology · 2016Article
- Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy.Brain : a journal of neurology · 2015Article
- The Potential Utility of Eye Movements in the Detection and Characterization of Everyday Functional Difficulties in Mild Cognitive Impairment.Neuropsychology review · 2015Review
- Eye movements in Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudying saccades is a useful tool to investigate brain function. There is still controversy regarding deficits in prosaccades in Alzheimer's disease (AD), and a study of saccades in subjects with mild cognitive impairment (MCI) has not been published to date.
methodsWe examined horizontal saccades in 10 healthy elderly, and 9 MCI and 9 AD patients. Two tasks were used: gap (fixation target extinguishes prior to target onset) and overlap (fixation stays on after target onset). Eye movements were recorded with the Skalar IRIS system.
results(1) Latencies were shorter in the gap than in the overlap task (a gap effect) in all three groups of subjects: healthy elderly, MCI and AD; (2) for both tasks, latency of saccades was longer for AD patients than for healthy and MCI subjects, and (3) accuracy and mean velocity were normal in MCI and AD subjects, however, variability in accuracy-speed was higher for AD patients than for healthy and MCI subjects in the overlap task.
conclusionsAbnormalities in reaction time and accuracy-speed variability reflect deficits in cerebral areas involved in the triggering and execution of saccades; a saccade test can be useful to follow up the evolution of MCI subjects as some of them may develop AD disease.
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