ArticleParasitology research2012
Characterization of microRNAs in Taenia saginata of zoonotic significance by Solexa deep sequencing and bioinformatics analysis.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Cestodes in the genomic era.Parasitology research · 2022Review
- Taenia solium and Taenia crassiceps: miRNomes of the larvae and effects of miR-10-5p and let-7-5p on murine peritoneal macrophages.Bioscience reports · 2019Article
- Comparative Identification of MicroRNAs inInsects · 2019Article
- Conservation and diversification of small RNA pathways within flatworms.BMC evolutionary biology · 2017Article
- Identification and profiling of Cyprinus carpio microRNAs during ovary differentiation by deep sequencing.BMC genomics · 2017Article
- High-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) reveals Argonaute-associated microRNAs and targets in Schistosoma japonicum.Parasites & vectors · 2015Article
- Application of small RNA technology for improved control of parasitic helminths.Veterinary parasitology · 2015Review
- Identification of microRNA genes in three opisthorchiids.PLoS neglected tropical diseases · 2015Article
- microRNA profiling in the zoonotic parasite Echinococcus canadensis using a high-throughput approach.Parasites & vectors · 2015Article
- MicroRNA-Sequence Profiling Reveals Novel Osmoregulatory MicroRNA Expression Patterns in Catadromous Eel Anguilla marmorata.PloS one · 2015Article
- microRNAs of parasitic helminths - Identification, characterization and potential as drug targets.International journal for parasitology. Drugs and drug resistance · 2014Review
- Detection of circulating parasite-derived microRNAs in filarial infections.PLoS neglected tropical diseases · 2014Article
- Identification and characterization of the expression profile of microRNAs in Anopheles anthropophagus.Parasites & vectors · 2014Article
- Identification and characterization of microRNAs in normal equine tissues by Next Generation Sequencing.PloS one · 2014Article
- Substantial loss of conserved and gain of novel MicroRNA families in flatworms.Molecular biology and evolution · 2013Article
- Identification of neglected cestode Taenia multiceps microRNAs by illumina sequencing and bioinformatic analysis.BMC veterinary research · 2013Article
- Comparative profiling of microRNAs in male and female adults of Ascaris suum.Parasitology research · 2013Article
- Identification of Dirofilaria immitis miRNA using illumina deep sequencing.Veterinary research · 2013Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The beef tapeworm Taenia saginata infects human beings with symptoms ranging from nausea, abdominal discomfort to digestive disturbances and intestinal blockage. In the present study, microRNA (miRNA) expressing profile in adult T. saginata was analyzed using Solexa deep sequencing and bioinformatics analysis. A total of 15.8 million reads was obtained by Solexa sequencing, and 13.3 million clean reads (1.73 million unique sequences) was obtained after removing reads smaller than 18 nt. Ten conserved miRNAs corresponding to 607,382 reads were found when matching the reads against known miRNAs of Schistosoma japonicum in miRBase database. The miR-71 had the most abundant expression in T. saginata, followed by miR-219-5p, but some other common miRNAs such as let-7, miR-40, and miR-103 were not identified in T. saginata. Nucleotide bias analysis found that the known miRNAs showed high bias and the uracil was the dominant nucleotide, particularly at the first and 11th positions which were almost at the beginning and middle of conserved miRNAs. One novel miRNA (Tsa-miR-001) corresponding to ten precursors was identified and confirmed by stem-loop RT-PCR. To our knowledge, this is the first report of miRNA profiles in T. saginata, which will contribute to better understanding of the complex biology of this zoonotic trematode. The reported data of T. saginata miRNAs should provide valuable references for miRNA studies of closed related zoonotic Taenia cestodes such as Taenia solium and Taenia asiatica.
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