ArticleJournal of cancer research and clinical oncology2012
Down-regulation of PDCD4 expression is an independent predictor of poor prognosis in human renal cell carcinoma patients.
Article in Journal of cancer research and clinical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis.Chinese journal of cancer · 2016Pooled it
- Targeting miRNAs in renal cell carcinoma: emerging therapeutic strategies.International journal of clinical oncology · 2025Review
- m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.NPJ precision oncology · 2025Article
- Tumor Suppressor p53 Down-Regulates Programmed Cell Death Protein 4 (PDCD4) Expression.Current oncology (Toronto, Ont.) · 2023Article
- A Review of Recent Research on the Role of MicroRNAs in Renal Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2021Review
- Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells.Cancers · 2021Article
- Circular RNA ITCH Is a Tumor Suppressor in Clear Cell Renal Cell Carcinoma Metastasis through miR-106b-5p/PDCD4 Axis.Journal of immunology research · 2021Observational
- Nuclear PDCD4 Expression Defines a Subset of Luminal B-Like Breast Cancers with Good Prognosis.Hormones & cancer · 2020Article
- Article
- MicroRNA-182 Promotes Cell Migration by Targeting Programmed Cell Death 4 in Hepatocellular Carcinoma Cells.OncoTargets and therapy · 2020Article
- Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions.International journal of molecular sciences · 2019Review
- Interrelation of the Circulating and Tissue MicroRNA-21 with Tissue PDCD4 Expression and the Invasiveness of Iraqi Female Breast Tumors.Indian journal of clinical biochemistry : IJCB · 2019Article
- Expression of tumor suppressor programmed cell death 4 in endometrioid endometrial carcinomas and clinicopathological significance.Oncology letters · 2018Article
- Long non-coding RNA XIST regulates PDCD4 expression by interacting with miR-21-5p and inhibits osteosarcoma cell growth and metastasis.International journal of oncology · 2017Article
- Downregulation of PDCD4 by miR-21 suppresses tumor transformation and proliferation in a nude mouse renal cancer model.Oncology letters · 2017Article
- Targeting the translation machinery in cancer.Nature reviews. Drug discovery · 2015Review
- microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate renal cancer cell invasion.Experimental cell research · 2014Article
- Integrative analysis of differential miRNA and functional study of miR-21 by seed-targeting inhibition in multiple myeloma cells in response to berberine.BMC systems biology · 2014Article
- Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma.Cell death & disease · 2013Article
- Prognostic significance of PDCD4 expression in human salivary adenoid cystic carcinoma.Medical oncology (Northwood, London, England) · 2013Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe tumor suppressor gene entitled programmed cell death 4 (PDCD4) encodes a protein that inhibits neoplastic transformation and invasion. The aim of this study was to investigate the expression of PDCD4 and its prognostic roles in human renal cell carcinoma (RCC). MATERIALS AND
methodsA total of 32 paired fresh tumor specimens and adjacent non-cancerous renal tissue from RCC patients by western blot to detect the difference of PDCD4 expression in tumor tissues and non-cancerous tissues. 66 RCC paraffin-embedded specimens and 18 normal renal tissues were analyzed by immunohistochemistry to investigate the association of PDCD4 expression with RCC clinicopathological features.
resultsPDCD4 expression was significantly decreased in RCC compared with normal renal tissues (P = 0.03), and it was found to be significantly associated with RCC metastasis (P = 0.007), tumor T-stage (P = 0.022) and tumor grade (P = 0.015). The mean overall survival was significantly decreased in the low PDCD4 group compared to the high PDCD4 group (low PDCD4: mean overall survival 41.9 months, high PDCD4: mean overall survival 52.9 months, P = 0.008).
conclusionPDCD4 expression strongly correlated to RCC stage, tumor grade, tumor metastasis and tumor-related death. PDCD4 expression was also appears to be a marker in RCC prognosis.
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