ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012
The performance of phase analysis of gated SPECT myocardial perfusion imaging in the presence of perfusion defects: a simulation study.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Prognostic significance of phase analysis using SPECT myocardial perfusion imaging in heart failure: a systematic review and meta-analysis.The international journal of cardiovascular imaging · 2025Pooled it
- Value of intraventricular dyssynchrony assessment by gated-SPECT myocardial perfusion imaging in the management of heart failure patients undergoing cardiac resynchronization therapy (VISION-CRT).Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Trial
- A New Method of Modeling the Multi-stage Decision-Making Process of CRT Using Machine Learning with Uncertainty Quantification.Journal of imaging informatics in medicine · 2026Article
- Clinical phenotypes among patients that underwent cardiac resynchronization therapy using unsupervised learning integrating gated SPECT.Nuclear medicine communications · 2025Article
- Left-ventricular dyssynchrony in viable myocardium by myocardial perfusion SPECT is predictive of mechanical response to CRT.Annals of nuclear medicine · 2021Article
- Phase analysis of gated myocardial perfusion SPECT and cardiac resynchronization therapy: The good, the bad, and the ugly.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Could myocardial viability be related to left ventricular dyssynchrony? Simultaneous evaluation by gated SPECT-MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Prognostic Value of Early Evaluation of Left Ventricular Dyssynchrony After Myocardial Infarction.Molecular imaging and biology · 2019Article
- Development and validation of a phase analysis tool to measure interventricular mechanical dyssynchrony from gated SPECT MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Measuring mechanical cardiac dyssynchrony in the 3-D era.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Right ventricular dyssynchrony in pulmonary hypertension: Phase analysis using FDG-PET imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Optimizing gated myocardial perfusion imaging processing for phase analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Nuclear Image-Guided Approaches for Cardiac Resynchronization Therapy (CRT).Current cardiology reports · 2016Review
- Stress-induced myocardial ischemia is associated with early post-stress left ventricular mechanical dyssynchrony as assessed by phase analysis of 201Tl gated SPECT myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2012Article
- Association of left ventricular mechanical dyssynchrony with survival benefit from revascularization: a study of gated positron emission tomography in patients with ischemic LV dysfunction and narrow QRS.European journal of nuclear medicine and molecular imaging · 2012Article
- Cardiac dyssynchrony: we have the tools. It is time to use them.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
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6 authors at 3 institutions in 2 countries.
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Abstract
backgroundPhase analysis has been developed and validated to measure left-ventricular dyssynchrony from gated SPECT myocardial perfusion imaging. The purpose of this study is to evaluate its performance in regions with perfusion defects.
methodsA special version of the eXtended CArdiac Torso digital phantom was developed to track B-spline points in each temporal frame. A region of 35 B-spline points in the inferior wall with normal and abnormal perfusion uptakes were simulated. Phase shifts were simulated in the same region, representing dyssynchronous contraction. Gated SPECT data were analyzed using a modified phase analysis algorithm, which tracked the same 35 B-spline points to calculate their phases.
resultsPhases and phase shifts measured in the B-spline points with perfusion uptake in the range of 50%-10% did not significantly differ from those measured in the same B-spline points with normal perfusion uptake.
conclusionPhase analysis can accurately measure phases in regions with abnormal perfusion uptake as low as 10% of the perfusion uptake in the normal regions, which corresponded to a regional signal-to-noise ratio (SNR) of 12.0 or greater. In 42 consecutive patients with myocardial infarction >20% of the left ventricle, only two patients had a SNR within the perfusion defects below that threshold.
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