Evidence map›Paper›PMID 22203319›Full record

Trial reportPsychopharmacology2012

Methylphenidate modulates sustained attention and cortical activation in survivors of traumatic brain injury: a perfusion fMRI study.

Junghoon Kim, John Whyte, Sunil Patel, Eduardo Europa, Jiongjiong Wang, H Branch Coslett, John A Detre

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Junghoon KimMoss Rehabilitation Research Institute, Albert Einstein Healthcare Network, 50 Township Line Rd., Elkins Park, PA 19027, USA. kimj@einstein.edu
John Whyte
Sunil Patel
Eduardo Europa
Jiongjiong Wang
H Branch Coslett
John A Detre
Einstein Healthcare Network · USMoss Rehabilitation Hospital · USUniversity of Pennsylvania · USUniversity of California, Los Angeles · US

Funding

statistics coreP30NS045839 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 2003 to 2017
$10.1M
NEUROPHYSIOLOGIC CORRELATES OF ATTENTION DEFICITSR24HD039621 · NICHD · MOSS REHABILITATION HOSPITAL · PI WHYTE, JOHN · 2000 to 2004
$4.7M
Research Methods for Cognitive RehabilitationR24HD050836 · NICHD · ALBERT EINSTEIN HEALTHCARE NETWORK · PI WHYTE, JOHN · 2005 to 2009
$4.4M
NICHD NIH HHS R24 HD039621NICHD NIH HHS R24 HD050836NICHD NIH HHS R24HD050836NICHD NIH HHS R24HD39621NINDS NIH HHS P30 NS045839NINDS NIH HHS P30NS045839
6 · The paper itself

Abstract

rationaleMethylphenidate (MPH), the most widely prescribed psychostimulant to treat many neuropsychiatric conditions, is reported to improve attention and speed of processing in survivors of traumatic brain injury (TBI). The neural correlate of this efficacy, however, remains unclear.

objectiveUsing perfusion functional magnetic resonance imaging (fMRI) as a biomarker of regional neural activity, the current study aimed to examine the neural correlates of single-dose (0.3 mg/kg) MPH administration in a randomized double-blind placebo-controlled crossover study design.

methodsTwenty-three individuals with moderate to severe TBI were tested on two occasions approximately 1 week apart. Perfusion fMRI scanning was carried out at rest and while participants performed cognitive tasks requiring sustained attention and working memory.

resultsBehaviorally, MPH significantly improved both accuracy and reaction time (RT) in the sustained attention task but only RT in the working memory task. A trend of global reduction of cerebral blood flow by MPH was observed in all task conditions including resting. Voxel-wise whole-brain analysis revealed an interaction effect of drug by condition (MPH-placebo X task-rest) for the sustained attention task in the left posterior superior parietal cortex and parieto-occipital junction (BA 7/19). The magnitude of drug-related deactivation of this area during task performance was correlated with improvement in RT.

conclusionSuppression of activity in this area during task performance may reflect a compensatory mechanism by which MPH ameliorates attention impairments in TBI.

Indexed as

AdultAttentionBrainBrain InjuriesCentral Nervous System StimulantsCognitionCross-Over StudiesDouble-Blind MethodFemaleHumansMagnetic Resonance ImagingMaleMemory, Short-TermMethylphenidateMiddle AgedReaction TimeCentral Nervous System StimulantsMethylphenidate

Identifiers

PMID22203319
PMCPMC3369011
OpenAlexW2036411130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.