Trial reportPsychopharmacology2012
Cue-elicited heart rate variability and attentional bias predict alcohol relapse following treatment.
Trial report in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Controlled breathing and heart rate variability biofeedback for substance use-related outcomes: A systematic review and meta-analysis.Addiction (Abingdon, England) · 2026Pooled it
- Risk and protective factors for relapse after residential substance use treatment: a systematic review and meta-analysis.BMC psychiatry · 2026Pooled it
- Does Attentional Bias Predict Relapse in Addiction? A Systematic Review of Longitudinal Studies.Brain and behavior · 2025Pooled it
- A Patient-Tailored Evidence-Based Approach for Developing Early Neuropsychological Training Programs in Addiction Settings.Neuropsychology review · 2019Pooled it
- Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone.Experimental and clinical psychopharmacology · 2025Trial
- Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment-seeking individuals with alcohol use disorder.Alcohol, clinical & experimental research · 2025Trial
- Baseline resting heart rate variability predicts post-traumatic stress disorder treatment outcomes in adults with co-occurring substance use disorders and post-traumatic stress.Psychophysiology · 2019Trial
- Effects of varenicline on alcohol cue reactivity in heavy drinkers.Psychopharmacology · 2017Trial
- Dopamine, urges to smoke, and the relative salience of drug versus non-drug reward.Social cognitive and affective neuroscience · 2015Trial
- Opioid attentional bias and cue-elicited craving predict future risk of prescription opioid misuse among chronic pain patients.Drug and alcohol dependence · 2014Trial
- Cardiac reactivity during the ascending phase of acute intravenous alcohol exposure and association with subjective perceptions of intoxication in social drinkers.Alcoholism, clinical and experimental research · 2014Trial
- Autonomic nervous system reactivity to alcohol-related cues in cocaine use disorder: vagal-sympathetic balance and clinical implications.Psychopharmacology · 2026Article
- Attentional Bias During a Novel Alcohol Cue Virtual Reality Paradigm.Alcohol, clinical & experimental research · 2026Article
- Multimodal Psychophysiological Assessment of Craving in Patients With Alcohol Dependence During Virtual Reality Cue Exposure: Exploratory Single-Arm Clinical Study.JMIR serious games · 2026Article
- Exploring gender differences in tobacco cue-induced craving and heart rate variability in individuals with a tobacco use disorder.Drug and alcohol dependence reports · 2026Article
- Changes in heart rate variability in patients of alcohol dependence syndrome-Do we have a biomarker for craving?Indian journal of psychiatry · 2025Article
- Psychological and Clinical Parameters as Predictors of Relapse in Alcohol-Dependent Patients During and After Extensive Inpatient Rehabilitation Treatment.Brain sciences · 2025Article
- Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition.Addiction neuroscience · 2024Article
- Heart rate variability: A primer for alcohol researchers.Alcohol (Fayetteville, N.Y.) · 2024Article
- Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition.bioRxiv : the preprint server for biology · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
rationaleIdentification of malleable neurocognitive predictors of relapse among alcohol-dependent individuals is important for the optimization of health care delivery and clinical services.
objectivesGiven that alcohol cue-reactivity can predict relapse, we evaluated cue-elicited high-frequency heart rate variability (HFHRV) and alcohol attentional bias (AB) as potential relapse risk indices.
methodAlcohol-dependent patients in long-term residential treatment who had participated in mindfulness-oriented therapy or an addiction support group completed a spatial cueing task as a measure of alcohol AB and an affect-modulated alcohol cue-reactivity protocol while HFHRV was assessed.
resultsPost-treatment HFHRV cue-reactivity and alcohol AB significantly predicted the occurrence and timing of relapse by 6-month follow-up, independent of treatment condition and after controlling for alcohol dependence severity. Alcohol-dependent patients who relapsed exhibited a significantly greater HFHRV reactivity to stress-primed alcohol cues than patients who did not relapse.
conclusionsCue-elicited HFHRV and alcohol AB can presage relapse and may therefore hold promise as prognostic indicators in clinical settings.
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