Evidence map›Paper›PMID 22203046›Full record

Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2012

Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach.

Giuseppe Filardo, Elizaveta Kon, Maria Teresa Pereira Ruiz, Franca Vaccaro, Rita Guitaldi, Alessandro Di Martino, Annarita Cenacchi, Pier Maria Fornasari, Maurilio Marcacci

4 registry-linked trialsAbstract readClinical TrialComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 163 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01782885 nacompletednot on this mapstarted 2013, after this paper: background citation

Comparison of Acetaminophen and Platelet-rich Plasma Therapy for the Treatment of Knee Osteoarthritis.

TypeinterventionalSponsorHospital Universitario Dr. Jose E. GonzalezRan2013 to 2015Enrolled543ConditionsKnee OsteoarthritisArmsIntra-articular injection of PRP, Acetaminophen
NCT04187183 nacompletednot on this mapstarted 2020, after this paper: background citation

Use of Fresh Platelet-rich Plasma With Concentrated Leukocytes or Fresh Platelet-rich Plasma Without Concentrated Leukocytes for Treating Knee Cartilage Degeneration: a Randomized Controlled Trial

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2020 to 2024Enrolled132ConditionsOsteoarthritis, KneeArmsFresh Platelet Rich Plasma with leukocyte, Fresh Platelet Rich Plasma without leukocyte
NCT04901273 narecruitingnot on this mapstarted 2021, after this paper: background citation

Homologous PRP Versus Placebo in the Infiltrative Treatment of Knee Osteoarthritis in Over 65 Years Old Patients.

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2021 to 2028Enrolled204ConditionsKnee OsteoarthritisArmsHomologous PRP injections, Placebo injection (saline solution)
NCT05080075 early_phase1completednot on this mapstarted 2021, after this paper: background citation

Platelet Rich Plasma in Knee Osteoarthritis: Establishing Clinical Guidelines to Predict and Maximize Outcomes

TypeinterventionalSponsorUniversity of Toledo Health Science CampusRan2021 to 2023Enrolled33ConditionsKnee OsteoarthritisArmsPlatelet Rich Plasma Injection
3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  9. Platelet-rich plasma injections induce disease-modifying effects in the treatment of osteoarthritis in animal models.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021
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103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Giuseppe FilardoBiomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1/10, 40136, Bologna, Italy.
Elizaveta Kon
Maria Teresa Pereira Ruiz
Franca Vaccaro
Rita Guitaldi
Alessandro Di Martino
Annarita Cenacchi
Pier Maria Fornasari
Maurilio Marcacci

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the safety and efficacy of two different approaches of platelet-rich plasma (PRP) production methods as intra-articular injection treatment for knee cartilage degenerative lesions and osteoarthritis (OA).

methodsThe study involved 144 symptomatic patients affected by cartilage degenerative lesions and OA. Seventy-two patients were treated with 3 injections of platelet concentrate prepared with a single-spinning procedure (PRGF), the other 72 with 3 injections of PRP obtained with a double-spinning approach. The patients were evaluated prospectively at the enrollment and at 2, 6, and 12 months' follow-up with IKDC, EQ-VAS and Tegner scores; adverse events and patient satisfaction were also recorded.

resultsBoth treatment groups presented a statistically significant improvement in all the scores evaluated at all the follow-up times. Better results were achieved in both groups in younger patients with a lower degree of cartilage degeneration. The comparative analysis showed similar improvements with the two procedures: in particular, IKDC subjective evaluation increased from 45.0 ± 10.1 to 59.0 ± 16.2, 61.3 ± 16.3, and 61.6 ± 16.2 at 2, 6, and 12 months in the PRGF group, and from 42.1 ± 13.5 to 60.8 ± 16.6, 62.5 ± 19.9, and 59.9 ± 20.0 at 2, 6, and 12 months in the PRP group, respectively. Concerning adverse events, more swelling (P = 0.03) and pain reaction (P = 0.0005), were found after PRP injections.

conclusionsAlthough PRP injections produced more pain and swelling reaction with respect to that produced by PRGF, similar results were found at the follow-up times, with a significant clinical improvement with respect to the basal level. Better results were achieved in younger patients with a low degree of cartilage degeneration. LEVEL OF EVIDENCE: II.

Indexed as

Platelet-Rich PlasmaAdultAgedCartilage DiseasesFemaleFollow-Up StudiesHumansInjections, Intra-ArticularLinear ModelsMaleMiddle AgedOrthopedic ProceduresOsteoarthritis, KneePatient SatisfactionProspective StudiesTreatment Outcome

Identifiers

PMID22203046

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.