ArticleUrology2012
Use of patient-specific MRI-based prostate mold for validation of multiparametric MRI in localization of prostate cancer.
Article in Urology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- A case of high-grade prostate cancer with low PSA levels.Urology case reports · 2025Article
- Deep Learning-based Anatomy-Aware Morph Model for Registration of Prostate Whole-Mount Histopathology to MRI.Radiology. Imaging cancer · 2025Article
- Direct correlation of MRI with histopathology in pediatric renal tumors through the use of a patient-specific 3-D-printed cutting guide: a feasibility study.Pediatric radiology · 2023Article
- Multiparametric magnetic resonance imaging for radiation therapy response monitoring in soft tissue sarcomas: a histology and MRI co-registration algorithm.Theranostics · 2023Article
- Lesion-specific 3D-printed moulds for image-guided tissue multi-sampling of ovarian tumours: A prospective pilot study.Frontiers in oncology · 2023Article
- Why Does Magnetic Resonance Imaging-Targeted Biopsy Miss Clinically Significant Cancer?The Journal of urology · 2022Article
- Imaging and biopsy of HIV-infected individuals undergoing analytic treatment interruption.Frontiers in medicine · 2022Article
- Registration of histopathology to magnetic resonance imaging of prostate cancer.Physics and imaging in radiation oncology · 2021Article
- Additive Manufacturing of Resected Oral and Oropharyngeal Tissue: A Pilot Study.International journal of environmental research and public health · 2021Article
- Liver-specific 3D sectioning molds for correlating in vivo CT and MRI with tumor histopathology in woodchucks (Marmota monax).PloS one · 2020Article
- Registration Accuracy of Patient-Specific, Three-Dimensional-Printed Prostate Molds for Correlating Pathology With Magnetic Resonance Imaging.IEEE transactions on bio-medical engineering · 2019Article
- MR Imaging-Histology Correlation by Tailored 3D-Printed Slicer in Oncological Assessment.Contrast media & molecular imaging · 2019Review
- A 3D-Printed Patient-Specific Phantom for External Beam Radiation Therapy of Prostate Cancer.Journal of engineering and science in medical diagnostics and therapy · 2018Article
- Quantitative transrectal shear wave elastography undergoing salvage extraperitoneal laparoscopic radical prostatectomy following failed radiotherapy.Surgical endoscopy · 2018Article
- Accurate validation of ultrasound imaging of prostate cancer: a review of challenges in registration of imaging and histopathology.Journal of ultrasound · 2018Review
- Article
- OptimizedJournal of medical imaging (Bellingham, Wash.) · 2018Article
- Improved Magnetic Resonance Imaging-Pathology Correlation With Imaging-Derived, 3D-Printed, Patient-Specific Whole-Mount Molds of the Prostate.Investigative radiology · 2017Article
- Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI.JCI insight · 2017Article
- Multiparametric magnetic resonance imaging characteristics of normal, benign and malignant conditions in the prostate.European radiology · 2017Article
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13 authors.
Funding
Abstract
objectiveTo demonstrate the use of a patient-specific magnetic resonance imaging (MRI)-based prostate mold to generate histologic sections that directly correlate to axial MRI slices in a patient with anteriorly located prostate cancer. Anteriorly located prostate cancer has traditionally been difficult to detect on digital rectal examination and transrectal ultrasound-guided biopsy. Multiparametric MRI has potential as a valuable tool for the diagnosis and focal treatment of prostate cancer. A significant difficulty to date has been accurate correlation between the magnetic resonance images and histopathologic specimens.
methodsA patient-specific mold from a preoperative T2-weighted MRI scan was created to hold and shape the prostate specimen. Slots for slicing were positioned at 6-mm increments coplanar to the axial MRI slices. After surgical excision, the specimen was inked to maintain the orientation and fixed in formalin. The seminal vesicles were excised, and the prostate was oriented in the mold such that the color-coding matched the anatomic labels on the mold. The specimen was sliced with a single blade and the resultant 6-mm tissue blocks were used for histologic analysis.
resultsPreoperative multiparametric MRI revealed a lesion in the right anterior transition zone that was positive on T2-weighed MRI, apparent diffusion coefficient maps of diffusion-weighted MRI, magnetic resonance spectroscopy, and dynamic contrast-enhanced MRI. The histologic sections obtained using the mold demonstrated a similar Gleason score 6 (3+3) lesion in the right anterior transition zone, correlating with the MRI findings.
conclusionThe use of patient-specific prostate molds to register the MRI findings with the histopathologic specimen in prostate cancer could offer several benefits compared with current specimen processing techniques. This technique might further validate MRI as an accurate tool for prostate cancer localization and staging.
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