ArticleNeurobiology of learning and memory2012
Female CGG knock-in mice modeling the fragile X premutation are impaired on a skilled forelimb reaching task.
Article in Neurobiology of learning and memory, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Gene×environment interactions in autism spectrum disorders.Current topics in developmental biology · 2023Review
- Neurodegenerative diseases associated with non-coding CGG tandem repeat expansions.Nature reviews. Neurology · 2022Review
- Adaptation of the Arizona Cognitive Task Battery for use with the Ts65Dn mouse model (Mus musculus) of Down syndrome.Journal of comparative psychology (Washington, D.C. : 1983) · 2017Article
- Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) Motor Dysfunction Modeled in Mice.Cerebellum (London, England) · 2016Review
- What has been learned from mouse models of the Fragile X Premutation and Fragile X-associated tremor/ataxia syndrome?The Clinical neuropsychologist · 2016Review
- CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome.Human molecular genetics · 2014Article
- Effects of acute sleep deprivation on motor and reversal learning in mice.Neurobiology of learning and memory · 2014Article
- CNS expression of murine fragile X protein (FMRP) as a function of CGG-repeat size.Human molecular genetics · 2014Article
- Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome.Neurobiology of aging · 2014Article
- Reduced activity-dependent protein levels in a mouse model of the fragile X premutation.Neurobiology of learning and memory · 2014Article
- Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome.Journal of neurodevelopmental disorders · 2014Review
- A cross-sectional analysis of orienting of visuospatial attention in child and adult carriers of the fragile X premutation.Journal of neurodevelopmental disorders · 2014Article
- Article
- Four decades of leading-edge research in the reproductive and developmental sciences: the Infant Primate Research Laboratory at the University of Washington National Primate Research Center.American journal of primatology · 2013Review
- Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms.Acta neuropathologica · 2013Review
- Neurocognitive endophenotypes in CGG KI and Fmr1 KO mouse models of Fragile X-Associated disorders: an analysis of the state of the field.F1000Research · 2013Review
- CGG trinucleotide repeat length modulates neural plasticity and spatiotemporal processing in a mouse model of the fragile X premutation.Hippocampus · 2012Article
- Distribution and frequency of intranuclear inclusions in female CGG KI mice modeling the fragile X premutation.Brain research · 2012Article
- Spatiotemporal processing deficits in female CGG KI mice modeling the fragile X premutation.Behavioural brain research · 2012Article
- The importance of considering all attributes of memory in behavioral endophenotyping of mouse models of genetic disease.Behavioral neuroscience · 2012Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The fragile X premutation is a tandem CGG trinucleotide repeat expansion in the fragile X mental retardation 1 (FMR1) gene between 55 and 200 repeats in length. A CGG knock-in (CGG KI) mouse has been developed that models the neuropathology and cognitive deficits reported in fragile X premutation carriers. Previous studies have demonstrated that CGG KI mice have spatiotemporal information processing deficits and impaired visuomotor function that worsen with increasing CGG repeat length. Since skilled forelimb reaching requires integration of information from the visual and motor systems, skilled reaching performance could identify potential visuomotor dysfunction in CGG KI mice. To characterize motor deficits associated with the fragile X premutation, 6 month old female CGG KI mice heterozygous for trinucleotide repeats ranging from 70-200 CGG in length were tested for their ability to learn a skilled forelimb reaching task. The results demonstrate that female CGG KI mice show deficits for learning a skilled forelimb reaching task compared to wildtype littermates, and that these deficits worsen with increasing CGG repeat lengths.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.