Evidence map›Paper›PMID 22202151›Full record

ReviewCurrent radiopharmaceuticals2011

Applications of 211At and 223Ra in targeted alpha-particle radiotherapy.

Ganesan Vaidyanathan, Michael R Zalutsky

Abstract readReview
In one paragraph

Review in Current radiopharmaceuticals, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
  2. Review
  3. Synthesis and in vitro characterization of [EJNMMI radiopharmacy and chemistry · 2025
    Article
  4. Article
  5. Article
  6. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  7. Targeted Radium Alpha Therapy in the Era of Nanomedicine: In Vivo Results.International journal of molecular sciences · 2024
    Review
  8. Review
  9. Efficient Production of the PET RadionuclidePharmaceuticals (Basel, Switzerland) · 2022
    Article
  10. Article
  11. Targeted α-therapy in non-prostate malignancies.European journal of nuclear medicine and molecular imaging · 2021
    Review
  12. Article
  13. Stabilization of anACS omega · 2021
    Article
  14. Article
  15. Article
  16. Labeling Monoclonal Antibody with α-emittingCancer biotherapy & radiopharmaceuticals · 2020
    Article
  17. Article
  18. Review
  19. Evidence of Local Concentration of α-Particles fromJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ganesan VaidyanathanDepartment of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA. ganesan.v@duke.edu
Michael R Zalutsky

Funding

TUMOR SUPPRESSOR GENES IN HUMAN MEDULLOBLASTOMAP50NS020023 · NINDS · DUKE UNIVERSITY · PI BIGNER, DARELL D · 1985 to 2013
$17.3M
RADIOTHERAPY USING MONOCLONAL ANTIBODIES AND ASTATINER01CA042324 · NCI · DUKE UNIVERSITY · PI ZALUTSKY, MICHAEL ROD · 1985 to 2020
$4.6M
NCI NIH HHS R01 CA042324NINDS NIH HHS P50 NS020023
6 · The paper itself

Abstract

Targeted radiotherapy using agents tagged with α-emitting radionuclides is gaining traction with several clinical trials already undertaken or ongoing, and others in the advanced planning stage. The most commonly used α-emitting radionuclides are 213Bi, 211At, 223Ra and 225Ac. While each one of these has pros and cons, it can be argued that 211At probably is the most versatile based on its half life, decay scheme and chemistry. On the other hand, for targeting bone metastases, 223Ra is the ideal radionuclide because simple cationic radium can be used for this purpose. In this review, we will discuss the recent developments taken place in the application of 211At-labeled radiopharmaceuticals and give an overview of the current status of 223Ra for targeted α-particle radiotherapy.

Indexed as

RadioimmunotherapyAlpha ParticlesAnimalsAntibodies, MonoclonalAstatineHumansNeoplasmsRadiopharmaceuticalsRadiumAntibodies, MonoclonalAstatineRadiopharmaceuticalsRadium

Identifiers

PMID22202151
PMCPMC3368371

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.