ReviewFrontiers in bioscience (Scholar edition)2012
Regulation of cardiac excitability by protein kinase C isozymes.
Review in Frontiers in bioscience (Scholar edition), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions.MedComm · 2025Review
- Metabolic and Mitochondrial Dysregulations in Diabetic Cardiac Complications.International journal of molecular sciences · 2025Review
- Ion channel trafficking implications in heart failure.Frontiers in cardiovascular medicine · 2024Review
- An Update on Protein Kinases as Therapeutic Targets-Part I: Protein Kinase C Activation and Its Role in Cancer and Cardiovascular Diseases.International journal of molecular sciences · 2023Review
- Pathophysiology of CaFrontiers in physiology · 2023Review
- Editorial: Transcription factors and arrhythmogenesis.Frontiers in physiology · 2023Article
- Article
- IiScience · 2022Article
- Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias.International journal of molecular sciences · 2022Review
- Programmed Exercise Attenuates Familial Hypertrophic Cardiomyopathy in Transgenic E22K MiceFrontiers in cardiovascular medicine · 2022Article
- Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective.Frontiers in cardiovascular medicine · 2022Review
- COVID-19 cardiovascular epidemiology, cellular pathogenesis, clinical manifestations and management.International journal of cardiology. Heart & vasculature · 2020Review
- Association of Regulatory Genetic Variants for Protein Kinase Cα with Mortality and Drug Efficacy in Patients with Heart Failure.Cardiovascular drugs and therapy · 2019Article
- Identification of small-molecule ion channel modulators in C. elegans channelopathy models.Nature communications · 2018Article
- Hydrogen sulphide increases pulmonary veins and atrial arrhythmogenesis with activation of protein kinase C.Journal of cellular and molecular medicine · 2018Article
- Different protein kinase C isoenzymes mediate inhibition of cardiac rapidly activating delayed rectifier KBritish journal of pharmacology · 2017Article
- Protein kinase C and cardiac dysfunction: a review.Heart failure reviews · 2017Review
- How cardiomyocytes sense pathophysiological stresses for cardiac remodeling.Cellular and molecular life sciences : CMLS · 2017Review
- Protein kinase C, an elusive therapeutic target?Nature reviews. Drug discovery · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cardiac excitability and electrical activity are determined by the sum of individual ion channels, gap junctions and exchanger activities. Electrophysiological remodeling during heart disease involves changes in membrane properties of cardiomyocytes and is related to higher prevalence of arrhythmia-associated morbidity and mortality. Pharmacological and genetic manipulation of cardiac cells as well as animal models of cardiovascular diseases are used to identity changes in electrophysiological properties and the molecular mechanisms associated with the disease. Protein kinase C (PKC) and several other kinases play a pivotal role in cardiac electrophysiological remodeling. Therefore, identifying specific therapies that regulate these kinases is the main focus of current research. PKC, a family of serine/threonine kinases, has been implicated as potential signaling nodes associated with biochemical and biophysical stress in cardiovascular diseases. In this review, we describe the role of PKC isozymes that are involved in cardiac excitability and discuss both genetic and pharmacological tools that were used, their attributes and limitations. Selective and effective pharmacological interventions to normalize cardiac electrical activities and correct cardiac arrhythmias will be of great clinical benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.