ArticleFrontiers in bioscience (Elite edition)2012
Lipidome analysis reveals antifungal polyphenol curcumin affects membrane lipid homeostasis.
Article in Frontiers in bioscience (Elite edition), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Overexpression of the White Opaque Switching Master Regulator Wor1 Alters Lipid Metabolism and Mitochondrial Function inJournal of fungi (Basel, Switzerland) · 2022Article
- Discovery of Natural Products With Antifungal Potential Through Combinatorial Synergy.Frontiers in microbiology · 2022Article
- Does Curcumin Have a Role in the Interaction between Gut Microbiota andPathogens (Basel, Switzerland) · 2020Article
- A detailed lipidomic study of human pathogenic fungi Candida auris.FEMS yeast research · 2020Article
- Anti-infective Properties of the Golden Spice Curcumin.Frontiers in microbiology · 2019Review
- Curcumin loaded self assembled lipid-biopolymer nanoparticles for functional food applications.Journal of food science and technology · 2015Article
- An assessment of growth media enrichment on lipid metabolome and the concurrent phenotypic properties of Candida albicans.PloS one · 2014Article
- Curcumin targets cell wall integrity via calcineurin-mediated signaling in Candida albicans.Antimicrobial agents and chemotherapy · 2014Article
- Lipidomics and in vitro azole resistance in Candida albicans.Omics : a journal of integrative biology · 2013Article
- Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans.International journal of microbiology · 2013Review
- The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance.The Biochemical journal · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This study shows that antifungal curcumin (CUR), significantly depletes ergosterol levels in Candida albicans. CUR while displaying synergy with fluconazole (FLC) lowers ergosterol. However, CUR alone at its synergistic concentration (lower than MIC50), could not affect ergosterol contents. For deeper insight of CUR effects on lipids, we performed high throughput mass spectroscopy (MS) based lipid profiling of C. albicans cells. The lipidome analysis revealed that there were no major changes in phosphoglycerides (PGLs) composition following CUR treatment of Candida, however, significant differences in molecular species of PGLs were detected. Among major SPLs, CUR treatment resulted in the reduction of ceramide and accumulation of IPCs levels. The lipidome of CUR treated cells confirmed a dramatic drop in the ergosterol levels with a simultaneous accumulation of its biosynthetic precursors. This was further supported by the fact that the mutants defective in ergosterol biosynthesis (ERG2 and ERG11) and those lacking the transcription factor regulating ergosterol biosynthesis, UPC2, were highly susceptible to CUR. Our study first time shows that CUR, for its antifungal activity, targets and down regulates delta 5, 6 desaturase (ERG3) resulting in depletion of ergosterol. This results in parallel accumulation of ergosterol biosynthetic precursors, generation of reactive oxygen species (ROS) and cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.