ReviewFrontiers in bioscience (Landmark edition)2012
Expressing genes do not forget their LINEs: transposable elements and gene expression.
Review in Frontiers in bioscience (Landmark edition), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Transcriptional Activation of Transposable Element (TE)-Associated Genes Is Frequently Associated with Altered Promoter Methylation in Placenta and Melanoma.International journal of molecular sciences · 2026Article
- Impact of prematurity on LINE-1 promoter methylation.Epigenomics · 2024Article
- The evolution of antimicrobial peptides in Chiroptera.Frontiers in immunology · 2023Article
- Human L1 Transposition Dynamics Unraveled with Functional Data Analysis.Molecular biology and evolution · 2020Article
- DNA methylation patterns of LINE-1 and Alu for pre-symptomatic dementia in type 2 diabetes.PloS one · 2020Article
- Agouti Signaling Protein and Its Receptors as Potential Molecular Markers for Intramuscular and Body Fat Deposition in Cattle.Frontiers in physiology · 2018Article
- Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer.Epigenetics · 2017Article
- Article
- An intronic LINE-1 insertion in MERTK is strongly associated with retinopathy in Swedish Vallhund dogs.PloS one · 2017Article
- The transposable element environment of human genes is associated with histone and expression changes in cancer.BMC genomics · 2016Article
- LINE1 insertions as a genomic risk factor for schizophrenia: Preliminary evidence from an affected family.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations.Mobile DNA · 2016Article
- Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving theTranslational neuroscience · 2015Review
- Transposable elements and psychiatric disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Review
- The vertebrate RCAN gene family: novel insights into evolution, structure and regulation.PloS one · 2014Article
- Characterization of OsMIK in a rice mutant with reduced phytate content reveals an insertion of a rearranged retrotransposon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- Genome-wide identification of genes regulated in trans by transposable element small interfering RNAs.RNA biology · 2013Article
- Is junk DNA bunk? A critique of ENCODE.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Common genetic variants in Wnt signaling pathway genes as potential prognostic biomarkers for colorectal cancer.PloS one · 2013Article
- Linear decay of retrotransposon antisense bias across genes is contingent upon tissue specificity.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Historically the accumulated mass of mammalian transposable elements (TEs), particularly those located within gene boundaries, was viewed as a genetic burden potentially detrimental to the genomic landscape. This notion has been strengthened by the discovery that transposable sequences can alter the architecture of the transcriptome, not only through insertion, but also long after the integration process is completed. Insertions previously considered harmless are now known to impact the expression of host genes via modification of the transcript quality or quantity, transcriptional interference, or by the control of pathways that affect the mRNA life-cycle. Conversely, several examples of the evolutionary advantageous impact of TEs on the host gene structure that diversified the cellular transcriptome are reported. TE-induced changes in gene expression can be tissue- or disease-specific, raising the possibility that the impact of TE sequences may vary during development, among normal cell types, and between normal and disease-affected tissues. The understanding of the rules and abundance of TE-interference with gene expression is in its infancy, and its contribution to human disease and/or evolution remains largely unexplored.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.