ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2012
Genomic impacts of chromosomal inversions in parapatric Drosophila species.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed.
- Rapid turnover of sex chromosomes is associated with speciation in Neotropical armored catfish Harttia (Siluriformes, Loricariidae).Biology direct · 2026Article
- Divergence at the IRX gene cluster underlies extreme trophic polymorphism in a cichlid fish (Herichthys minckleyi).Communications biology · 2026Article
- Review
- 3D Genome Constrains Breakpoints of Inversions That Can Act as Barriers to Gene Flow in the Stickleback.Molecular ecology · 2025Article
- Reproductive Barriers and Genomic Hotspots of Adaptation During Allopatric Species Divergence.Molecular ecology · 2025Article
- Testing the evolutionary theory of inversion polymorphisms in the yellow monkeyflower (Mimulus guttatus).Nature communications · 2024Article
- Article
- Transition to Self-compatibility Associated With Dominant S-allele in a Diploid Siberian Progenitor of Allotetraploid Arabidopsis kamchatica Revealed by Arabidopsis lyrata Genomes.Molecular biology and evolution · 2023Article
- The genetic basis of conspicuous coloration in the Guadeloupean anole: Evolution by sexual and ecological selection.Ecology and evolution · 2023Article
- Experimental introgression in Drosophila: Asymmetric postzygotic isolation associated with chromosomal inversions and an incompatibility locus on the X chromosome.Molecular ecology · 2023Article
- The Genetic Differentiation ofFrontiers in genetics · 2022Article
- Article
- Extensive Recombination Suppression and Epistatic Selection Causes Chromosome-Wide Differentiation of a Selfish Sex Chromosome inGenetics · 2020Article
- The importance of intrinsic postzygotic barriers throughout the speciation process.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Analysis of structural variants in four African cichlids highlights an association with developmental and immune related genes.BMC evolutionary biology · 2020Article
- Genomic Resources for Darters (Percidae: Etheostominae) Provide Insight into Postzygotic Barriers Implicated in Speciation.Molecular biology and evolution · 2020Article
- Higher Gene Flow in Sex-Related Chromosomes than in Autosomes during Fungal Divergence.Molecular biology and evolution · 2020Article
- Weak genetic structure despite strong genomic signal in lesser sandeel in the North Sea.Evolutionary applications · 2020Article
- Population Genomics on the Fly: Recent Advances in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Host plant-related genomic differentiation in the European cherry fruit fly, Rhagoletis cerasi.Molecular ecology · 2019Article
12 more citing papers are in PubMed but not listed here.
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Abstract
Chromosomal inversions impact genetic variation and facilitate speciation in part by reducing recombination in heterokaryotypes. We generated multiple whole-genome shotgun sequences of the parapatric species pair Drosophila pseudoobscura and Drosophila persimilis and their sympatric outgroup (Drosophila miranda) and compared the average pairwise differences for neutral sites within, just outside and far outside of the three large inversions. Divergence between D. pseudoobscura and D. persimilis is high inside the inversions and in the suppressed recombination regions extending 2.5 Mb outside of inversions, but significantly lower in collinear regions further from the inversions. We observe little evidence of decreased divergence predicted to exist in the centre of inversions, suggesting that gene flow through double crossovers or gene conversion is limited within the inversion, or selection is acting within the inversion to maintain divergence in the face of gene flow. In combination with past studies, we provide evidence that inversions in this system maintain areas of high divergence in the face of hybridization, and have done so for a substantial period of time. The left arm of the X chromosome and chromosome 2 inversions appear to have arisen in the lineage leading to D. persimilis approximately 2 Ma, near the time of the split of D. persimilis-D. pseudoobscura-D. miranda, but likely fixed within D. persimilis much more recently, as diversity within D. persimilis is substantially reduced inside and near these two inversions. We also hypothesize that the inversions in D. persimilis may provide an empirical example of the 'mixed geographical mode' theory of inversion origin and fixation, whereby allopatry and secondary contact both play a role.
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