ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2012
Extensive linkage disequilibrium and parallel adaptive divergence across threespine stickleback genomes.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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88 citing papers in PubMed.
- Genomic Signatures of Selection Are Enriched in Differentially Expressed Genes in Sticklebacks Adapting to Contrasting Environments.Genome biology and evolution · 2026Article
- On the Causes of Correlated Genomic Ancestry Across Contrasting Hybridization Histories in a Monkeyflower Species Pair.Molecular ecology · 2026Article
- On the causes of correlated genomic ancestry across contrasting hybridization histories in a monkeyflower species pair.bioRxiv : the preprint server for biology · 2026Article
- Rare jackpot individuals drive rapid adaptation in Threespine Stickleback.Nature communications · 2026Article
- The hybrid history of zebrafish.G3 (Bethesda, Md.) · 2025Article
- Parallel evolution in an island archipelago revealed by genomic sequencing of Hipposideros leaf-nosed bats.Evolution; international journal of organic evolution · 2024Article
- Polygenic architecture of flowering time and its relationship with local environments in the grass Brachypodium distachyon.Genetics · 2024Article
- Deciphering the population structure and genetic basis of growth traits from whole-genome resequencing of the leopard coral grouper (Zoological research · 2024Article
- Single nucleotide polymorphisms in the MRFs gene family associated with growth in Nile tilapia.Molecular biology reports · 2024Article
- Genomics of Secondarily Temperate Adaptation in the Only Non-Antarctic Icefish.Molecular biology and evolution · 2023Article
- Characterizing phenotypic diversity in marine populations of the threespine stickleback.Scientific reports · 2022Article
- Comparative phylogeography of two commensal rat species (Ecology and evolution · 2022Article
- Whole genome resequencing reveals signatures of rapid selection in a virus-affected commercial fishery.Molecular ecology · 2022Article
- Article
- Demography and selection analysis of the incipient adaptive radiation of a Hawaiian woody species.PLoS genetics · 2022Article
- Predicting future from past: The genomic basis of recurrent and rapid stickleback evolution.Science advances · 2021Article
- A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.Nature communications · 2021Article
- Genomic Resources for Darters (Percidae: Etheostominae) Provide Insight into Postzygotic Barriers Implicated in Speciation.Molecular biology and evolution · 2020Article
- Divergent selection and drift shape the genomes of two avian sister species spanning a saline-freshwater ecotone.Ecology and evolution · 2019Article
- Strong selection pressures maintain divergence on genomic islands in Atlantic cod (Gadus morhua L.) populations.Genetics, selection, evolution : GSE · 2019Article
28 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Population genomic studies are beginning to provide a more comprehensive view of dynamic genome-scale processes in evolution. Patterns of genomic architecture, such as genomic islands of increased divergence, may be important for adaptive population differentiation and speciation. We used next-generation sequencing data to examine the patterns of local and long-distance linkage disequilibrium (LD) across oceanic and freshwater populations of threespine stickleback, a useful model for studies of evolution and speciation. We looked for associations between LD and signatures of divergent selection, and assessed the role of recombination rate variation in generating LD patterns. As predicted under the traditional biogeographic model of unidirectional gene flow from ancestral oceanic to derived freshwater stickleback populations, we found extensive local and long-distance LD in fresh water. Surprisingly, oceanic populations showed similar patterns of elevated LD, notably between large genomic regions previously implicated in adaptation to fresh water. These results support an alternative biogeographic model for the stickleback radiation, one of a metapopulation with appreciable bi-directional gene flow combined with strong divergent selection between oceanic and freshwater populations. As predicted by theory, these processes can maintain LD within and among genomic islands of divergence. These findings suggest that the genomic architecture in oceanic stickleback populations may provide a mechanism for the rapid re-assembly and evolution of multi-locus genotypes in newly colonized freshwater habitats, and may help explain genetic mapping of parallel phenotypic variation to similar loci across independent freshwater populations.
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