ArticleClinical rheumatology2012
Delineating psychological and biomedical profiles in a heterogeneous fibromyalgia population using cluster analysis.
Article in Clinical rheumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Cluster analysis in fibromyalgia: a systematic review.Rheumatology international · 2024Pooled it
- Cognitive behavioural therapies for fibromyalgia.The Cochrane database of systematic reviews · 2013Pooled it
- Distinct effects of fibromyalgia pain, depression and anxiety on perception of affective touch and pain.The Journal of physiology · 2026Article
- Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: a population-based cohort study.BMC medicine · 2025Article
- Childhood abuse and health outcomes in patients with fibromyalgia: a cross-sectional exploratory study of the moderating effects of pain catastrophizing and mindfulness.BMC musculoskeletal disorders · 2025Article
- Impact of homeostatic body hydration status, evaluated by hemodynamic measures, on different pain sensitization paths to a chronic pain syndrome.Scientific reports · 2024Article
- Virtual embodiment in fibromyalgia.Scientific reports · 2023Article
- Relevance of Religiosity for Coping Strategies and Disability in Patients with Fibromyalgia Syndrome.Journal of religion and health · 2022Article
- Coexistence of fibromyalgia and metabolic syndrome in females: The effects on fatigue, clinical features, pain sensitivity, urinary cortisol and norepinephrine levels: A cross-sectional study.Archives of rheumatology · 2021Article
- Modifiable Psychological Factors Affecting Functioning in Fibromyalgia.Journal of clinical medicine · 2021Article
- Data-Driven Cluster Analysis of Oxidative Stress Indexes in relation to Vitamin D Level, Age, and Metabolic Control in Patients with Type 2 Diabetes on Metformin Therapy.Oxidative medicine and cellular longevity · 2021Article
- Subgrouping a Large U.S. Sample of Patients with Fibromyalgia Using the Fibromyalgia Impact Questionnaire-Revised.International journal of environmental research and public health · 2020Article
- Assessing our approach to diagnosing Fibromyalgia.Expert review of molecular diagnostics · 2020Review
- Perfectionism and Pain Intensity in Women with Fibromyalgia: Its Influence on Activity Avoidance from The Contextual Perspective.International journal of environmental research and public health · 2020Article
- Pain Catastrophizing in Older Adults with Chronic Pain: The Mediator Effect of Mood Using a Path Analysis Approach.Journal of clinical medicine · 2020Article
- Somatic symptom presentations in women with fibromyalgia are differentially associated with elevated depression and anxiety.Journal of health psychology · 2020Article
- Identification of MOR-Positive B Cell as Possible Innovative Biomarker (Mu Lympho-Marker) for Chronic Pain Diagnosis in Patients with Fibromyalgia and Osteoarthritis Diseases.International journal of molecular sciences · 2020Observational
- Article
- The Relationship of Intimate Partner Violence With Psychiatric Disorders and Severity of Pain Among Female Patients With Fibromyalgia.Archives of rheumatology · 2019Article
- Pain Intensity, Disability, and Quality of Life in Patients with Chronic Low Back Pain: Does Age Matter?Pain medicine (Malden, Mass.) · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The heterogeneity of patients meeting American College of Rheumatology (ACR) criteria for a diagnosis of fibromyalgia (FM) challenges our ability to understand the underlying pathogenesis and to optimize treatment of this enigmatic disorder. Our goal was to discern clinically relevant subgroups across multiple psychological and biomedical domains to better characterize the phenomenology of FM. Women meeting 1990 ACR criteria for FM (N = 107) underwent psychological (childhood trauma, mood, anxiety, and stress) and biomedical (neuroendocrine, immune, and metabolic) testing. Cluster analysis identified four distinct subgroups. Subgroups I, II, and III exhibited profiles that included high psychological distress. Subgroup I was further distinguished by a history of childhood maltreatment and hypocortisolism, and these women reported the most pain and disability. Subgroup II evinced more physiological dysregulation and also reported high levels of pain, fatigue, and disability. Subgroup III was characterized by normal biomarkers and reported intermediate pain severity with higher global functioning. Subgroup IV was distinguished by their psychological well-being, reporting less disability and pain. Our findings underscore the heterogeneity of both psychological and physiological features among FM patients presenting with nearly identical tender point counts. This subgroup categorization is compatible with hypothesized pathogenetic mechanisms of early trauma, stress system dysregulation, and pro-inflammatory bias, each prominent in some but not all FM patients. Appreciation of distinct FM subgroup features is invaluable for selecting the most appropriate treatment modalities.
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Registered trials
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