ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2012
The spectrum of renal histologies seen in HIV with outcomes, prognostic indicators and clinical correlations.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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53 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2018Guideline
- The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa.BMC nephrology · 2019Trial
- Chronic kidney disease in patients infected with human immunodeficiency virus (HIV) in an urban cohort.PloS one · 2019Trial
- HIV-positive-to-HIV-positive kidney transplantation--results at 3 to 5 years.The New England journal of medicine · 2015Trial
- The Spectrum of HIV-Associated Kidney Pathology at a Tertiary Centre in South Africa.International journal of nephrology · 2026Article
- Pathogenesis of HIV-associated nephropathy in children and adolescents: taking a hard look 40 years later in the era of gene-environment interactions.American journal of physiology. Renal physiology · 2024Review
- Article
- Prevalence and predictors of long-term progression of chronic kidney disease in people with HIV in Ghana from 2003-2018.BMC nephrology · 2024Article
- HIV-associated nephropathy in children: challenges in a resource-limited setting.Pediatric nephrology (Berlin, Germany) · 2023Review
- Effect of tenofovir containing ART on renal function in patients with moderate/severe reduced creatinine clearance at baseline: A retrospective study at two referral hospitals in Namibia.Pharmacology research & perspectives · 2023Article
- Management of Type 2 Diabetes Mellitus and Kidney Failure in People with HIV-Infection in Africa: Current Status and a Call to Action.HIV/AIDS (Auckland, N.Z.) · 2023Review
- Chronic Kidney Disease and Nephrology Care in People Living with HIV in Central/Eastern Europe and Neighbouring Countries-Cross-Sectional Analysis from the ECEE Network.International journal of environmental research and public health · 2022Article
- Genetic Variants ofKidney international reports · 2022Article
- Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV.Kidney international reports · 2022Article
- Clinicopathological correlation of kidney disease in HIV infection pre- and post-ART rollout.PloS one · 2022Article
- Primary membranous glomerulonephritis with negative serum PLA2R in haemophilia A successfully managed with rituximab - case report and review of the literature.BMC nephrology · 2021Article
- Histopathological Pattern of Kidney Diseases Among HIV-Infected Treatment-Naïve Patients in Kano, Nigeria.International journal of nephrology and renovascular disease · 2021Article
- HIV protease inhibitor ritonavir induces renal fibrosis and dysfunction: role of platelet-derived TGF-β1 and intervention via antioxidant pathways.AIDS (London, England) · 2020Article
- Current Management Strategies of Chronic Kidney Disease in Resource-Limited Countries.International journal of nephrology and renovascular disease · 2020Review
- HIV, drugs and the kidney.Drugs in context · 2020Review
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Authors and funding
5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTwo hundred and twenty-one HIV-positive renal biopsies were analysed from Groote Schuur Hospital to determine outcomes and prognostic indicators based on histology and clinical features.
methodsThe histology findings were compared with patient demographics, clinical and renal parameters, mortality, CD4 count and date of commencing combined anti-retroviral therapy (cART). Follow-up was between 1 and 3.5 years.
resultsWe found a spectrum of renal histologies in HIV-positive patients of which HIV-associated nephropathy (HIVAN) was the most common histology. cART reduced the mortality in those with any feature of HIVAN by 57% [adjusted hazard ratio (AHR) 0.43, 95% confidence interval (CI) 0.22-0.85]. Of those patients with HIVAN who died, 79% died of renal failure as registered on their death certificate. Proteinuria and microcysts were shown to be poor prognostic indicators (AHR 1.36: 1.09-1.70 and 2.04: 1.24-3.37). In patients with HIVAN alone followed for up to 2 years on cART, estimated glomerular filtration rate remained stable and there was a trend towards decreased proteinuria. cART improved survival in patients with isolated immune complex disease.
conclusionsAs mortality is improved in patients with any feature of HIVAN or isolated immune complex disease, cART should be initiated once any of these histological features are established. We believe the spectrum of disease that constitutes HIVAN needs to be more specifically defined. The ultimate outcome may be determined by the histological subtype.
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