Evidence map›Paper›PMID 22200541›Full record

ReviewExperimental neurology2012

Treatments to restore respiratory function after spinal cord injury and their implications for regeneration, plasticity and adaptation.

Himanshu Sharma, Warren J Alilain, Anita Sadhu, Jerry Silver

Abstract readReview
In one paragraph

Review in Experimental neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

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  13. Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Himanshu SharmaDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Warren J Alilain
Anita Sadhu
Jerry Silver
University School · USCase Western Reserve University · US

Funding

FACTORS AFFECTING REGENERATION THRU THE GLIAL SCARR01NS025713 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SILVER, JERRY · 1988 to 2016
$3.1M
Functional Regeneration and Sprouting of Respiratory Pathways After Spinal Cord IR01NS060767 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SILVER, JERRY · 2008 to 2011
$1.4M
NINDS NIH HHS R01 NS025713NINDS NIH HHS R01 NS060767
6 · The paper itself

Abstract

Spinal cord injury (SCI) often leads to impaired breathing. In most cases, such severe respiratory complications lead to morbidity and death. However, in the last few years there has been extensive work examining ways to restore this vital function after experimental spinal cord injury. In addition to finding strategies to rescue breathing activity, many of these experiments have also yielded a great deal of information about the innate plasticity and capacity for adaptation in the respiratory system and its associated circuitry in the spinal cord. This review article will highlight experimental SCI resulting in compromised breathing, the various methods of restoring function after such injury, and some recent findings from our own laboratory. Additionally, it will discuss findings about motor and CNS respiratory plasticity and adaptation with potential clinical and translational implications.

Indexed as

AnimalsCervical VertebraeDisease Models, AnimalNerve RegenerationNeuronal PlasticityRespirationRespiration DisordersRespiratory CenterSpinal CordSpinal Cord Injuries

Identifiers

PMID22200541
PMCPMC3334458
OpenAlexW1969426981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.