Evidence map›Paper›PMID 22199407›Full record

ArticleTetrahedron letters2011

Synthesis of the C21-C34 fragment of antascomicin B.

John M Hutchison, Andrew S Gibson, David T Williams, Matthias C McIntosh

Abstract read
In one paragraph

Article in Tetrahedron letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John M HutchisonUniversity of Arkansas, 119 Chemistry Building, Fayetteville, AR 72701, USA.
Andrew S Gibson
David T Williams
Matthias C McIntosh

Funding

RESEARCH PILOT PROJECT PROGRAMP30RR031154 · NCRR · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI KOEPPE, ROGER E · 2010 to 2011
$2.2M
NCRR NIH HHS P30 RR031154
6 · The paper itself

Abstract

The C21-C34 fragment of the potent FKBP12-binding macrolide antascomicin B was prepared using Ireland-Claisen and allylic diazene rearrangements to establish the C26/C27 and the C23 stereocenters, respectively. Directed hydrogenation installed the C29 β-configuration. The fragment possesses 7 of the 11 fixed stereocenters contained in the natural product.

Identifiers

PMID22199407
PMCPMC3244276

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.