ArticleAging2011
Robust nuclear lamina-based cell classification of aging and senescent cells.
Article in Aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Aging and Altered Gravity: A Cellular Perspective.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- The weakness of senescent dermal fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Expression of lamin C2 in mammalian oocytes.PloS one · 2020Article
- Increased Expression of Maturation Promoting Factor Components Speeds Up Meiosis in Oocytes from Aged Females.International journal of molecular sciences · 2018Article
- Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells.Journal of the American Heart Association · 2017Article
- Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells.Disease models & mechanisms · 2016Review
- Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level.SpringerPlus · 2016Article
- Nuclear Mechanics and Stem Cell Differentiation.Stem cell reviews and reports · 2015Review
- The Mechanobiology of Aging.Annual review of biomedical engineering · 2015Review
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- An inhibitory role of progerin in the gene induction network of adipocyte differentiation from iPS cells.Aging · 2013Article
- Quantification of the Spatial Organization of the Nuclear Lamina as a Tool for Cell Classification.ISRN molecular biology · 2013Review
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in the shape of the nuclear lamina are exhibited in senescent cells, as well as in cells expressing mutations in lamina genes. To identify cells with defects in the nuclear lamina we developed an imaging method that quantifies the intensity and curvature of the nuclear lamina. We show that this method accurately describes changes in the nuclear lamina. Spatial changes in nuclear lamina coincide with redistribution of lamin A proteins and local reduction in protein mobility in senescent cell. We suggest that local accumulation of lamin A in the nuclear envelope leads to bending of the structure. A quantitative distinction of the nuclear lamina shape in cell populations was found between fresh and senescent cells, and between primary myoblasts from young and old donors. Moreover, with this method mutations in lamina genes were significantly distinct from cells with wild-type genes. We suggest that this method can be applied to identify abnormal cells during aging, in in vitro propagation, and in lamina disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.