ArticleNature2011
Purkinje neuron synchrony elicits time-locked spiking in the cerebellar nuclei.
Article in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 237 papers.
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Who cites it
237 citing papers in PubMed, 372 citations in OpenAlex.
- Cerebellar rhythms: mechanisms, functions and translational opportunities.Nature reviews. Neuroscience · 2026Review
- Focal Task-Specific Dystonia Beyond M1: Network Adaptations and a Causal-Architecture Taxonomy of Dystonia.Brain sciences · 2026Article
- Time-Dependent Enhancement of Motor Dexterity and Cerebellar Function via Premotor-Cerebellar Associative Stimulation.The European journal of neuroscience · 2026Article
- Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation.International journal of molecular sciences · 2026Review
- Cerebellar neural populations orchestrate dopamine reward signaling with single-trial precision.Nature communications · 2026Article
- Cerebellum-inspired memtransistors enable emergent differentiation for hardware-efficient novelty detection.Nature communications · 2026Article
- Polarity-dependent modulation of sensory circuits by cerebellar tDCS: local and distant effects.Scientific reports · 2026Article
- Cerebellar microRNA-206 tunes Purkinje neuron firing dynamics to control sensorimotor gating.bioRxiv : the preprint server for biology · 2026Article
- Random innervation of cerebellar Purkinje cells as a substrate for diverse representational learning.bioRxiv : the preprint server for biology · 2026Article
- Behavioral correlates of Purkinje cell ensemble covariance.Nature communications · 2026Article
- Steady-state Purkinje cell activity has limited predictive power for cerebellar output in disease.The Journal of physiology · 2026Article
- Region- and cell type-specific changes in gene expression in the cerebellum after classical fear conditioning.Communications biology · 2026Article
- Cerebellar Time and Relative Time: A Comparator-Based Dynamical Timing Model and its Relevance to Psychopathology and Therapies.Cerebellum (London, England) · 2026Review
- Coordination of spike timing among the neurons of the cerebellum.Research square · 2026Article
- Effects of Short-Term Synaptic Plasticity in Feedforward Inhibitory Circuits on Cerebellar Responses to Repetitive Sensory Input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex.eLife · 2025Article
- Tonic GABAScientific reports · 2025Article
- Coordination of spike timing among the neurons of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- The electrogenicity of the NaeLife · 2025Article
177 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
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Abstract
An unusual feature of the cerebellar cortex is that its output neurons, Purkinje cells, release GABA (γ-aminobutyric acid). Their high intrinsic firing rates (50 Hz) and extensive convergence predict that their target neurons in the cerebellar nuclei would be largely inhibited unless Purkinje cells pause their spiking, yet Purkinje and nuclear neuron firing rates do not always vary inversely. One indication of how these synapses transmit information is that populations of Purkinje neurons synchronize their spikes during cerebellar behaviours. If nuclear neurons respond to Purkinje synchrony, they may encode signals from subsets of inhibitory inputs. Here we show in weanling and adult mice that nuclear neurons transmit the timing of synchronous Purkinje afferent spikes, owing to modest Purkinje-to-nuclear convergence ratios (∼40:1), fast inhibitory postsynaptic current kinetics (τ(decay) = 2.5 ms) and high intrinsic firing rates (∼90 Hz). In vitro, dynamically clamped asynchronous inhibitory postsynaptic potentials mimicking Purkinje afferents suppress nuclear cell spiking, whereas synchronous inhibitory postsynaptic potentials entrain nuclear cell spiking. With partial synchrony, nuclear neurons time-lock their spikes to the synchronous subpopulation of inputs, even when only 2 out of 40 afferents synchronize. In vivo, nuclear neurons reliably phase-lock to regular trains of molecular layer stimulation. Thus, cerebellar nuclear neurons can preferentially relay the spike timing of synchronized Purkinje cells to downstream premotor areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.