ArticleJournal of molecular evolution2011
Two polymorphic residues account for the differences in DNA binding and transcriptional activation by NF-κB proteins encoded by naturally occurring alleles in Nematostella vectensis.
Article in Journal of molecular evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- NF-κB: A Diverse and Multifunctional Transcription Factor in Holozoans.Molecular biology and evolution · 2026Review
- Looking Down on NF-κB.Molecular and cellular biology · 2020Review
- Transcription factor NF-κB is modulated by symbiotic status in a sea anemone model of cnidarian bleaching.Scientific reports · 2017Article
- Current directions and future perspectives from the third Nematostella research conference.Zoology (Jena, Germany) · 2015Article
- Production of a reference transcriptome and transcriptomic database (EdwardsiellaBase) for the lined sea anemone, Edwardsiella lineata, a parasitic cnidarian.BMC genomics · 2014Article
- A report from the second Nematostella vectensis research conference.Development genes and evolution · 2013Article
- Isolation of DNA, RNA and protein from the starlet sea anemone Nematostella vectensis.Nature protocols · 2013Article
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Authors and funding
7 authors.
Funding
Abstract
The NF-κB family of transcription factors is activated in response to many environmental and biological stresses, and plays a key role in innate immunity across a broad evolutionary expanse of animals. A simple NF-κB pathway is present in the sea anemone Nematostella vectensis, an important model organism in the phylum Cnidaria. Nematostella has previously been shown to have two naturally occurring NF-κB alleles (Nv-NF-κB-C and Nv-NF-κB-S) that encode proteins with different DNA-binding and transactivation abilities. We show here that polymorphic residues 67 (Cys vs. Ser) and 269 (Ala vs. Glu) play complementary roles in determining the DNA-binding activity of the NF-κB proteins encoded by these two alleles and that residue 67 is primarily responsible for the difference in their transactivation ability. Phylogenetic analysis indicates that Nv-NF-κB-S is the derived allele, consistent with its restricted geographic distribution. These results define polymorphic residues that are important for the DNA-binding and transactivating activities of two naturally occurring variants of Nv-NF-κB. The implications for the appearance of the two Nv-NF-κB alleles in natural populations of sea anemones are discussed.
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