Trial reportBrain structure & function2012
Differences in integrity of white matter and changes with training in spelling impaired children: a diffusion tensor imaging study.
Trial report in Brain structure & function, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Training-Induced Neural Plasticity in Youth: A Systematic Review of Structural and Functional MRI Studies.Frontiers in human neuroscience · 2020Pooled it
- Neuroimaging of reading intervention: a systematic review and activation likelihood estimate meta-analysis.PloS one · 2014Pooled it
- Improved frontoparietal white matter integrity in overweight children is associated with attendance at an after-school exercise program.Developmental neuroscience · 2014Trial
- White Matter Diffusivity Predicts Change in Sight Word Reading Following Continuous Theta Burst Stimulation to the Left Temporal Parietal Junction.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Cerebello-Cerebral Pathways Contribute to Written Word Production.Neurobiology of language (Cambridge, Mass.) · 2025Article
- White matter associations with spelling performance.Brain structure & function · 2024Article
- Exploring brain plasticity in developmental dyslexia through implicit sequence learning.NPJ science of learning · 2024Article
- The right hemisphere's capacity for language: evidence from primary progressive aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Correlation between diffusion tensor imaging measures and the reading and cognitive performance of Arabic readers: dyslexic children perspective.Neuroradiology · 2020Article
- Word learning reveals white matter plasticity in preschool children.Brain structure & function · 2020Article
- Myelin Water Imaging Demonstrates Lower Brain Myelination in Children and Adolescents With Poor Reading Ability.Frontiers in human neuroscience · 2020Article
- White matter alterations and tract lateralization in children with dyslexia and isolated spelling deficits.Human brain mapping · 2019Article
- Diffusion MRI of white matter microstructure development in childhood and adolescence: Methods, challenges and progress.Developmental cognitive neuroscience · 2018Review
- Rapid and widespread white matter plasticity during an intensive reading intervention.Nature communications · 2018Article
- Emergence of the neural network underlying phonological processing from the prereading to the emergent reading stage: A longitudinal study.Human brain mapping · 2018Article
- Atypical White Matter Connectivity in Dyslexic Readers of a Fairly Transparent Orthography.Frontiers in psychology · 2018Article
- All Wrapped Up: Environmental Effects on Myelination.Trends in neurosciences · 2017Review
- Changes of White Matter Diffusion Anisotropy in Response to a 6-Week iPad Application-Based Occupational Therapy Intervention in Children with Surgically Treated Hydrocephalus: A Pilot Study.Neuropediatrics · 2016Article
- Brain white matter structure and COMT gene are linked to second-language learning in adults.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Plasticity of left perisylvian white-matter tracts is associated with individual differences in math learning.Brain structure & function · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
While the functional correlates of spelling impairment have been rarely investigated, to our knowledge no study exists regarding the structural characteristics of spelling impairment and potential changes with interventions. Using diffusion tensor imaging at 3.0 T, we here therefore sought to investigate (a) differences between children with poor spelling abilities (training group and waiting group) and controls, and (b) the effects of a morpheme-based spelling intervention in children with poor spelling abilities on DTI parameters. A baseline comparison of white matter indices revealed significant differences between controls and spelling-impaired children, mainly located in the right hemisphere (superior corona radiata (SCR), posterior limb of internal capsule, superior longitudinal fasciculus). After 5 weeks of training, spelling ability improved in the training group, along with increases in fractional anisotropy and decreases of radial diffusivity in the right hemisphere compared to controls. In addition, significantly higher decreases of mean diffusivity in the right SCR for the spelling-impaired training group compared to the waiting group were observed. Our results suggest that spelling impairment is associated with differences in white-matter integrity in the right hemisphere. We also provide first indications that white matter changes occur during successful training, but this needs to be more specifically addressed in future research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.