ArticleDevelopment genes and evolution2012
Molecular mechanisms of EGF signaling-dependent regulation of pipe, a gene crucial for dorsoventral axis formation in Drosophila.
Article in Development genes and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- A non-canonical Raf function is required for dorsal-ventral patterning during Drosophila embryogenesis.Scientific reports · 2022Article
- Unscrambling butterfly oogenesis.BMC genomics · 2013Article
- Co-option of a coordinate system defined by the EGFr and Dpp pathways in the evolution of a morphological novelty.EvoDevo · 2013Article
- The Capicua repressor--a general sensor of RTK signaling in development and disease.Journal of cell science · 2012Review
- Transcriptional interpretation of the EGF receptor signaling gradient.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- EGFR-dependent downregulation of Capicua and the establishment of Drosophila dorsoventral polarity.FlyArticle
- Maternal control of the Drosophila dorsal-ventral body axis.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
During Drosophila oogenesis the expression of the sulfotransferase Pipe in ventral follicle cells is crucial for dorsoventral axis formation. Pipe modifies proteins that are incorporated in the ventral eggshell and activate Toll signaling which in turn initiates embryonic dorsoventral patterning. Ventral pipe expression is the result of an oocyte-derived EGF signal which down-regulates pipe in dorsal follicle cells. The analysis of mutant follicle cell clones reveals that none of the transcription factors known to act downstream of EGF signaling in Drosophila is required or sufficient for pipe regulation. However, the pipe cis-regulatory region harbors a 31-bp element which is essential for pipe repression, and ovarian extracts contain a protein that binds this element. Thus, EGF signaling does not act by down-regulating an activator of pipe as previously suggested but rather by activating a repressor. Surprisingly, this repressor acts independent of the common co-repressors Groucho or CtBP.
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