ArticleNature methods2011
Visualizing adenosine-to-inosine RNA editing in the Drosophila nervous system.
Article in Nature methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Spatial transcriptomics reveals laminar and cell-type-specific A-to-I RNA editing signatures in the macaque cortex.Nature communications · 2026Article
- SARS-CoV-2-induced dysregulation in ADAR editing patterns persists post viral clearance in individuals with mild COVID-19.Frontiers in cellular and infection microbiology · 2026Article
- Emerging strategies for the genetic dissection of gene functions, cell types, and neural circuits in the mammalian brain.Molecular psychiatry · 2022Review
- From Antisense RNA to RNA Modification: Therapeutic Potential of RNA-Based Technologies.Biomedicines · 2021Review
- Spatially regulated editing of genetic information within a neuron.Nucleic acids research · 2020Article
- Current strategies for Site-Directed RNA Editing using ADARs.Methods (San Diego, Calif.) · 2019Review
- Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries.Nucleic acids research · 2019Article
- Illuminating spatial A-to-I RNA editing signatures within theProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Adenosine to Inosine editing frequency controlled by splicing efficiency.Nucleic acids research · 2016Article
- Molecular biology of insect sodium channels and pyrethroid resistance.Insect biochemistry and molecular biology · 2014Article
- Assessing the validity and reproducibility of genome-scale predictions.Bioinformatics (Oxford, England) · 2013Article
- Deciphering the functions and regulation of brain-enriched A-to-I RNA editing.Nature neuroscience · 2013Review
- RNA editing regulates transposon-mediated heterochromatic gene silencing.Nature communications · 2013Article
- The ADAR protein family.Genome biology · 2012Review
- A screening protocol for identification of functional mutants of RNA editing adenosine deaminases.Current protocols in chemical biology · 2012Article
- Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila.Nature communications · 2012Article
- Making sense out of nonsense to visualize editing in the fly nervous system.Nature methods · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Informational recoding by adenosine-to-inosine RNA editing diversifies neuronal proteomes by chemically modifying structured mRNAs. However, techniques for analyzing editing activity on substrates in defined neurons in vivo are lacking. Guided by comparative genomics, here we reverse-engineered a fluorescent reporter sensitive to Drosophila melanogaster adenosine deaminase that acts on RNA (dADAR) activity and alterations in dADAR autoregulation. Using this artificial dADAR substrate, we visualized variable patterns of RNA-editing activity in the Drosophila nervous system between individuals. Our results demonstrate the feasibility of structurally mimicking ADAR substrates as a method to regulate protein expression and, potentially, therapeutically repair mutant mRNAs. Our data suggest variable RNA editing as a credible molecular mechanism for mediating individual-to-individual variation in neuronal physiology and behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.