ArticleMolecular and cellular biochemistry2012
De novo characterization of the antler tip of Chinese Sika deer transcriptome and analysis of gene expression related to rapid growth.
Article in Molecular and cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Integrated mRNA and miRNA Analysis Reveals Layer-Specific Mechanisms of Antler Yield Variation in Sika Deer.Animals : an open access journal from MDPI · 2025Article
- Characterizing therapeutic effects of velvet antler using different omics strategies.Journal of traditional and complementary medicine · 2025Review
- Single-cell transcriptome analysis reveals elongation and ossification characteristics of antlers.Frontiers in veterinary science · 2025Article
- The Genetic Basis Underpinning Sexually Selected Traits across Different Animal Lineages: Are There Genetic Mechanisms in Common?Animals : an open access journal from MDPI · 2024Review
- Comparative transcriptome analysis provides insight into the molecular targets and signaling pathways of deer TGF-1 regulating chondrocytes proliferation and differentiation.Molecular biology reports · 2023Article
- MiRNA Profiling and Its Potential Roles in Rapid Growth of Velvet Antler in Gansu Red Deer (Genes · 2023Article
- Identification and Characterization of Alternative Splicing Variants and Positive Selection Genes Related to Distinct Growth Rates of Antlers Using Comparative Transcriptome Sequencing.Animals : an open access journal from MDPI · 2022Article
- Characterization of Embryonic Skin Transcriptome inG3 (Bethesda, Md.) · 2020Article
- Comparative transcriptome analysis of the main beam and brow tine of sika deer antler provides insights into the molecular control of rapid antler growth.Cellular & molecular biology letters · 2020Article
- Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler.International journal of genomics · 2020Article
- The biomolecular characterization of a finger ring contextually dated to the emergence of the Early Neolithic from Syltholm, Denmark.Royal Society open science · 2020Article
- Analysis of genetic information from the antlers of Rangifer tarandus (reindeer) at the rapid growth stage.PloS one · 2020Article
- DNA methylation and mRNA expression of COL6A3 in antler mesenchyme of female and male reindeer.Genes & genomics · 2019Article
- Proteomic analysis of the effects of antler extract on chondrocyte proliferation, differentiation and apoptosis.Molecular biology reports · 2019Article
- Full-length transcriptome and microRNA sequencing reveal the specific gene-regulation network of velvet antler in sika deer with extremely different velvet antler weight.Molecular genetics and genomics : MGG · 2019Article
- Transcriptomic analysis of different tissue layers in antler growth Center in Sika Deer (Cervus nippon).BMC genomics · 2019Article
- Identification of the miRNA-mRNA regulatory network of antler growth centers.Journal of biosciences · 2019Article
- Article
- Endangered Père David's deer genome provides insights into population recovering.Evolutionary applications · 2018Article
- Identifying deer antler uhrf1 proliferation and s100a10 mineralization genes using comparative RNA-seq.Stem cell research & therapy · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deer antlers are well known for their regeneration and rapid growth. However, little is known about the genes that are involved in their development, especially the molecular mechanisms responsible for rapid growth. In the present study, we produced more than 41 million sequencing reads using the Illumina sequencing platform. These reads were assembled into 89,001 unique sequences (mean size: 450 bp), representing more than 58 times as many Sika deer sequences previously available in the NCBI database (as of Sep 15, 2011). Based on a similarity search with known proteins, we identified 40,088 sequences with a cut-off E value of 10(-5). Assembled sequences were then annotated using Gene ontology terms, Clusters of Orthologous Groups classifications, and Kyoto Encyclopedia of Genes and Genomes pathways. In addition, we found a number of highly expressed genes involved in the regulation of Sika deer antler rapid growth, including transcription factors, signaling molecules, and extracellular matrix proteins. Our data represent the most comprehensive sequence resource available for the deer antler and provide a basis for new research on deer antler molecular genetics and functional genomics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.