Evidence map›Paper›PMID 22198319›Full record

ArticleBiochimica et biophysica acta2012

Adiponectin deficiency: role in chronic inflammation induced colon cancer.

Arpit Saxena, Alexander Chumanevich, Emma Fletcher, Bianca Larsen, Kirby Lattwein, Kamaljeet Kaur, Raja Fayad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Three adiponectin rs1501299G/T, rs822395A/C, and rs822396A/G polymorphisms and risk of cancer development: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013
    Pooled it
  2. Adiponectin (ADIPOQ) rs2241766 G/T polymorphism is associated with risk of cancer: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013
    Pooled it
  3. Trial
  4. Review
  5. Adipokines: masterminds of metabolic inflammation.Nature reviews. Immunology · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Role of Adipose Tissue in Inflammatory Bowel Disease.International journal of molecular sciences · 2021
    Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Adiponectin as Link Factor between Adipose Tissue and Cancer.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Arpit SaxenaDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, 921 Assembly Street, Room 402, USA.
Alexander Chumanevich
Emma Fletcher
Bianca Larsen
Kirby Lattwein
Kamaljeet Kaur
Raja Fayad
University of South Carolina · USUniversity of South Carolina Sumter · US

Funding

University of South Carolina Initiative for Maximizing Student DevelopmentR25GM076277 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ELY, BERT · 2006 to 2015
$2.6M
NIGMS NIH HHS R25 GM076277
6 · The paper itself

Abstract

Adiponectin (APN), an adipokine, exerts an anti-inflammatory and anti-cancerous activity with its role in glucose and lipid metabolism and its absence related to several obesity related malignancies including colorectal cancer. The aim of this study is to determine the effect of APN deficiency on the chronic inflammation-induced colon cancer. This was achieved by inducing inflammation and colon cancer in both APN knockout (KO) and C57B1/6 wild type (WT) mice. They were divided into four treatment groups (n=6): 1) control (no treatment); 2) treatment with three cycles of dextran sodium sulfate (DSS); 3) weekly doses of 1,2-dimethylhydrazine (DMH) (20mg/kg of mouse body weight) for twelve weeks; 4) a single dose of DMH followed by 3 cycles of DSS (DMH+DSS). Mice were observed for diarrhea, stool hemoccult, and weight loss and were sacrificed on day 153. Tumor area and number were counted. Colonic tissues were collected for Western blot and immunohistochemistry analyses. APNKO mice were more protected than WT mice from DSS induced colitis during first DSS cycle, but lost this protection during the second and the third DSS cycles. APNKO mice had significantly severe symptoms and showed greater number and larger area of tumors with higher immune cell infiltration and inflammation than WT mice. This result was further confirmed by proteomic study including pSTAT3, pAMPK and Cox-2 by western blot and Immunohistochemistry. Conclusively, APN deficiency contributes to inflammation-induced colon cancer. Hence, APN may play an important role in colorectal cancer prevention by modulating genes involved in chronic inflammation and tumorigenesis.

Indexed as

Adenylate KinaseAdiponectinAnimalsChronic DiseaseColonic NeoplasmsCyclooxygenase 2Enzyme-Linked Immunosorbent AssayImmunohistochemistryInflammationMaleMiceMice, KnockoutSTAT3 Transcription FactorAdenylate KinaseAdiponectinCyclooxygenase 2Stat3 protein, mouseSTAT3 Transcription Factor

Identifiers

PMID22198319
PMCPMC3961716
OpenAlexW2035034509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.